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The X-ray Crystal Structures of Human α-Phosphomannomutase 1 Reveal the Structural Basis of Congenital Disorder of Glycosylation Type 1a*
Congential disorder of glycosylation type 1a (CDG-1a) is a congenital disease characterized by severe defects in nervous system development. It is caused by mutations in α-phosphomannomutase (ofExpand
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  • Open Access
Analysis of the substrate specificity loop of the HAD superfamily cap domain.
The haloacid dehalogenase (HAD) superfamily includes a variety of enzymes that catalyze the cleavage of substrate C-Cl, P-C, and P-OP bonds via nucleophilic substitution pathways. All members possessExpand
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  • Open Access
Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis.
Lactococcus lactis beta-phosphoglucomutase (beta-PGM) catalyzes the interconversion of beta-d-glucose 1-phosphate (beta-G1P) and beta-d-glucose 6-phosphate (G6P), forming beta-d-glucoseExpand
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Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis.
Tauhe beta-phosphoglucomutase (beta-PGM) of the haloacid dehalogenase enzyme superfamily (HADSF) catalyzes the conversion of beta-glucose 1-phosphate (betaG1P) to glucose 6-phosphate (G6P) using Asp8Expand
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Relaxing the coenzyme specificity of 1,3-propanediol oxidoreductase from Klebsiella pneumoniae by rational design.
1,3-Propanediol has wide applications for large volume markets, particularly in the polymer business. Microbial production of 1,3-propanediol has been considered as a competitor to the traditionalExpand
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Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate.
Activated Lactococcus lactis beta-phosphoglucomutase (betaPGM) catalyzes the conversion of beta-d-glucose 1-phosphate (betaG1P) derived from maltose to beta-d-glucose 6-phosphate (G6P). ActivationExpand
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  • Open Access
Catalytic Cycling in â-Phosphoglucomutase : A Kinetic and Structural Analysis
Lactococcus lactisâ-phosphoglucomutase ( â-PGM) catalyzes the interconversion of â-D-glucose 1-phosphate ( â-G1P) andâ-D-glucose 6-phosphate (G6P), forming â-D-glucose 1,6-(bis)phosphate ( âG16P) asExpand
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  • Open Access
Sugaring-out extraction of 2,3-butanediol from fermentation broths
Abstract Sugaring-out is a novel phase separation method which was found firstly in the separation of acetonitrile. Nowadays sugaring-out extraction was tried in the recovery of metal ions,Expand
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Partition behavior of hydrophilic diols in an ethanol/ammonium sulfate salting‐out extraction system
It is important to investigate the partition behavior of hydrophilic alcohols at different process parameters in order to have a deep understanding of the salting‐out extraction technique and toExpand
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Salting-out Extraction of 2,3-Butanediol from Jerusalem artichoke-based Fermentation Broth
Abstract The removal of solid impurities and separation of target products from a fermentation broth is becoming more tedious with the utilization of lignocelluloses as source of substrate.Expand
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