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A Novel TRPC6 Mutation That Causes Childhood FSGS
Background TRPC6, encoding a member of the transient receptor potential (TRP) superfamily of ion channels, is a calcium-permeable cation channel, which mediates capacitive calcium entry into theExpand
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Intracellular calcium activates TRPM2 and its alternative spliced isoforms
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca2+-permeable, nonselective cation channel that is involved in oxidative stress-induced cell death and inflammation processes.Expand
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TRPM7-Mediated Ca2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation
Rationale: Cardiac fibrosis contributes to pathogenesis of atrial fibrillation (AF), which is the most commonly sustained arrhythmia and a major cause of morbidity and mortality. Although it has beenExpand
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Molecular Determinants of Mg2+ and Ca2+ Permeability and pH Sensitivity in TRPM6 and TRPM7*
The channel kinases TRPM6 and TRPM7 have recently been discovered to play important roles in Mg2+ and Ca2+ homeostasis, which is critical to both human health and cell viability. However, theExpand
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Role of TRP channels in the cardiovascular system.
The transient receptor potential (TRP) superfamily consists of a large number of nonselective cation channels with variable degree of Ca(2+)-permeability. The 28 mammalian TRP channel proteins can beExpand
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Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity
TRPM6 is crucial for human Mg2+ homeostasis as patients carrying TRPM6 mutations develop hypomagnesemia and secondary hypocalcemia (HSH). However, the activation mechanism of TRPM6 has remainedExpand
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Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity
TRPM2 is a Ca2+-permeable nonselective cation channel that plays important roles in oxidative stress–mediated cell death and inflammation processes. However, how TRPM2 is regulated underExpand
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Functional expression and characterization of four novel neurotoxins from sea anemone Anthopleura sp.
  • L. Wang, J. Ou, +8 authors A. Xu
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2 January 2004
The genes of four novel neurotoxins, named Hk2a, Hk7a, Hk8a, and Hk16a, were obtained from sea anemone Anthopleura sp. All four neurotoxins were composed of 47 amino acid residues and the variableExpand
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Stationary phase protein overproduction is a fundamental capability of Escherichia coli.
  • J. Ou, L. Wang, +4 authors A. Xu
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 30 January 2004
Although Escherichia coli is well studied and various recombinant E. coli protein expression systems have been developed, people usually consider the rapid growing (log phase) culture of E. coli asExpand
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