Jianxun Mi

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Mexiletine and lidocaine are widely used class IB anti-arrhythmic drugs that are considered to act by blocking voltage-gated open sodium currents for treatment of ventricular arrhythmias and relief of pain. To gain mechanistic insights into action of anti-arrhythmics, we characterized biophysical properties of Nav1.5 and Nav1.7 channels stably expressed in(More)
Blind source extraction (BSE) is particularly attractive to solve blind signal mixture problems where only a few source signals are desired. Many existing BSE methods do not take into account the existence of noise and can only work well in noise-free environments. In practice, the desired signal is often contaminated by additional noise. Therefore, we try(More)
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