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We present a generic Lagrangian, in arbitrary spacetime dimension D, describing the interaction of a dilaton, a graviton and an antisymmetric tensor of arbitrary rank d. For each D and d, we find " solitonic " black˜p-brane solutions where˜p = ˜ d−1 and˜d = D−d−2. These solutions display a spacetime singularity surrounded by an event horizon, and are(More)
We review the status of solitons in superstring theory, with a view to understanding the strong coupling regime. These solitonic solutions are non-singular field configurations which solve the empty-space low-energy field equations (generalized, whenever possible, to all orders in α ′), carry a non-vanishing topological " magnetic " charge and are(More)
BACKGROUND qualitative and quantitative changes in human mitochondrial DNA (mtDNA) have been implicated in various cancer types. A 4,977 bp deletion in the major arch of the mitochondrial genome is one of the most common mutations associated with a variety of human diseases and aging. METHODS we conducted a comprehensive study on clinical features and(More)
Astrocytes play multiple roles in physiological and pathological conditions in brain. However, little is known about the alterations of astrocytes in age-related changes, and few aging models of the astrocytes in vitro have been established. Therefore, in the present study, we used d-galactose (D-Gal) to establish astrocyte aging model to explore the(More)
OBJECTIVE The aim of this study was to investigate the effects of carnosine on the bioenergetic profile of cultured cortical astrocytes under normal and ischemic conditions. METHODS The Seahorse Bioscience XF96 Extracellular Flux Analyzer was used to measure the oxygen consumption rates (OCRs) and extracellular acidification rates (ECARs) of cultured(More)
BACKGROUND Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic diseases and cancer. METHODS To investigate whether mtDNA haplogroups contribute to the occurrence of cancer in a specific Chinese population,(More)
We investigate how the four-dimensional noncommutative open string/Yang-Mills theory behaves under a general non-perturbative quantum SL(2, Z) symmetry transformation. We discuss this by considering D3 branes in a constant background of axion, dilaton, and electric and magnetic fields (including both E ⊥ B and E||B cases) in the respective decoupling limit.(More)