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—With the increasing prevalence of large scale cloud computing environments, how to place requested applications into available computing servers regarding to energy consumption has become an essential research problem, but existing application placement approaches are still not effective for live applications with dynamic characters. In this paper, we(More)
Chronic stress and neuronal vulnerability have recently been recognized as factors contributing to cognitive disorders. One way to modify neuronal vulnerability is through mediation of phosphodiesterase 2 (PDE2), an enzyme that exerts its action on cognitive processes via the control of intracellular second messengers, cGMP and, to a lesser extent, cAMP.(More)
The p38 MAPK signaling pathway plays a pivotal role in inflammation. Targeting p38 MAPK may be a potential strategy for the treatment of inflammatory diseases. In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide, IL-1β and IL-6, decreased the levels of iNOS,(More)
With energy and power costs increasing as the size of IT infrastructures grows, virtualization technologies enable scalable management for large scale of virtual machines running on physical systems, and virtualization-based green cloud computing paradigm is springing up to provide a scalable and energy-efficient network software application (NetApp in(More)
Secoisolariciresinoldiglycoside (SDG), a predominant lignan in flaxseed, has antioxidant activity as a dietary supplement. The purpose of the present study was to investigate the antidepressant-like effect and the possible mechanism of flaxseed SDG when the ovariectomized mice were exposed to the unpredictable chronic mild stress procedure. Chronic stress(More)
Natural and man-made disasters can significantly impact both people and environments. Enhanced effect can be achieved through dynamic networking of people, systems and procedures and seamless integration of them to fulfil mission objectives with service-oriented sensor systems. However, the benefits of integration of services will not be realised unless we(More)
The increasing complexity and dynamics of grid environments have posed great challenges for secure and privacy-preserving collaboration in a virtual organization. In this paper, we propose PEACE-VO, a secure policy-enabled collaboration framework for virtual organizations. PEACE-VO employs role mapping to define trust relationships across autonomous(More)
Grid computing has emerged as a new paradigm of distributed computing technology on large-scale resource sharing and coordinated problem solving. Based on a proposed Web service-based grid architecture, we have designed a service grid middleware system called CROWN which aims to promote the utilization of valuable resources and cooperation of researchers(More)
Depression-pain dyad involves a series of pathological changes including the dysfunction of neuroendocrine and immune networks. Depression and pain influence each other, but the mechanisms are still obscure. The present study aimed to investigate the effect of ferulic acid (FA) on reserpine-induced pain and depression-like behaviors in mice. The results(More)
Ferulic acid is a polyphenol that has antioxidant, anti-inflammatory and anticancer properties. The present study analyzed the antidepressant-like potential of ferulic acid using two well-validated mouse models of despair test, tail suspension and forced swim tests. The results suggested that ferulic acid treatment at doses of 10, 20, 40 and 80 mg/kg (p.o.)(More)