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AIM Investigate the promoter methylation of the Thrombospondin-1 (TSP1) gene in gastric cardia adenocarcinoma (GCA). METHODS MSP approach, immunohistochemistry method, and RT-PCR were used respectively to examine the promoter methylation of TSP1, its protein and mRNA expression in tumors and corresponding normal tissues. The expression and concentration(More)
Our studies and those of many others have implicated hepatocyte necrosis and apoptosis mediated by fibrinogen-like protein-2 (fgl2) prothrombinase and tumor necrosis factor receptor (TNFR) in the development of fulminant viral hepatitis, a disease with a mortality rate greater than 80% in cases lacking immediate organ transplantation. This study was(More)
OBJECTIVE To explore the molecular events and mechanism in the carcinogenesis of esophageal epithelium in the high incidence area of esophageal carcinoma. METHODS Epithelial cells collected from the high incidence area of esophageal carcinoma were used to detect DNA content and ploidy by propidium iodide(PI) stain. The expressions of p53, p16 and cyclin(More)
BACKGROUND   The venom of spiders may inspire new drugs to treat carcinoma. The aim of this study was to investigate the effect of P38 MAPK on tumor necrosis factor-related apoptosis of lung adenocarcinoma cell line by spider venom. METHODS   Lung adenocarcinoma A549 cells were cultured in PRMI-1640 medium and the apoptosis rate was observed after(More)
By using PCR technique and microsatellite marks, this paper studied the DNA polymorphism of peach aphid (Myzus persicae) under UV-radiation. The fragments of three primers were amplified, and the gene diversity and the rate of loci polymorphisms of their genomic DNA, which could reflect the damage degree of DNA after UV-radiation, were measured. The results(More)
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