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Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells
TLDR
It is shown that a novel ginsenoside derivative, Rh2E2, is as effective as aspirin in preventing the development of AOM/DSS-induced colorectal cancer and suppresses tumor growth and metastasis in a LLC-1 xenograft. Expand
Quantitation of phlorizin and phloretin using an ultra high performance liquid chromatography-electrospray ionization tandem mass spectrometric method.
TLDR
A sensitive and selective ultra high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS) method for the determination of phlorizin and phloretin in human plasma has been firstly developed and offers advantages in terms of expediency, suitability, and suitability. Expand
Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death
TLDR
Thalidezine is a novel AMPK activator which has great potential to be further developed into a safe and effective intervention for apoptosis- or multidrug-resistant cancers. Expand
Comparison of two exploratory data analysis methods for classification of Phyllanthus chemical fingerprint: unsupervised vs. supervised pattern recognition technologies
TLDR
This study is the first holistic comparison of supervised and unsupervised pattern recognition technologies in the TCM chemical fingerprinting and showed advantages in sample classification and data mining, respectively. Expand
Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells
TLDR
5-FU treatment is suggested to have caused unexpected changes in intracellular purine polls, such as increases in deoxyadenosine triphosphate (dATP), adenosine-triph phosphate (ATP, guanosine Triphosphates (GTP) pools, and further elucidation of the mechanism of action of 5-FU in causing these changes should enhance development of strategies that will increase the anticancer activity of 4FU while decreasing its resistance. Expand
SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells.
TLDR
Collateral sensitivity in MDR cancer cells is demonstrated by simultaneous inhibition of SERCA and P-gp for the first time, and in vivo studies confirmed that celastrol suppressed tumor growth and metastasis by SERCA-mediated calcium mobilization. Expand
Determination of corilagin in rat plasma using a liquid chromatography-electrospray ionization tandem mass spectrometric method.
TLDR
A sensitive and simple liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method for the determination of corilagin in rat plasma has been developed and the practical utility was confirmed in pilot plasma concentration studies in rats following oral administration. Expand
Improving the detection sensitivity of chromatography by stochastic resonance.
TLDR
This review summary summarizes the use of basic SR, optimization of parameters and its modifications, including periodic modulation stochastic resonance (PSRA), linear modulation Stochastic Resonance (LSRA), single-well potential stochastically resonance (SSR) and the Duffing oscillator algorithm (DOA) for amplifying sub-threshold small signals. Expand
Quantitation of kudinoside A, kudinoside D and kudinoside F in human plasma using a high performance liquid chromatography-electrospray ionization tandem mass spectrometric method.
A sensitive and selective high performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method for the simultaneous determination of kudinoside A, kudinoside D and kudinoside F inExpand
Does academic interest play a more important role in medical sciences than in other disciplines? A nationwide cross-sectional study in China
TLDR
The results show that no particular academic interest in medical Sciences is needed to achieve academic success when compared with natural sciences and engineering programmes, but success in medical sciences requires more academic interest than success in humanities or social sciences. Expand
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