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Deeper Chemical Perceptions for Better Traditional Chinese Medicine Standards
TLDR
In this review, the latest exploratory research in TCM chemistry analytical techniques and methods is summarized in order to begin to develop responses to scientific issues.
Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells
TLDR
Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds, were isolated from the of Alisma plantago-aquatica Linn and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76–38.20 μmol/L.
New depsides from the roots of Salvia miltiorrhiza and their radical-scavenging capacity and protective effects against H2O2-induced H9c2 cells.
TLDR
Phytochemical investigation of the roots of Salvia miltiorrhiza led to isolations of two new depsides (1-2), along with thirteen known compounds (3-15), which were found to exhibit stronger free radical scavenging capacity and possessed significant protective effects against H2O2-induced H9c2 apoptosis in low concentrations.
Traditional Chinese medicine (TCM) as a source of new anticancer drugs.
TLDR
The research and development process, the molecular mechanisms of action, and the clinical evaluation associated with some exemplificative anticancer drugs based on TCM are discussed, along with their potential of integration in western medicine.
Implementation of a Single Quadrupole Mass Spectrometer for Fingerprint Analysis: Venenum bufonis as a Case Study
TLDR
Based on this study, an MSF based on single quadrupole mass spectrometry method was established, and was successfully used for the quality control of Venenum bufonis, a famous TCM which was used clinically for cancer treatment in China.
An integrated strategy for holistic quality identification of Chinese patent medicine: Liuwei Dihuang Pills as a case study.
TLDR
The SIM identification method by a single analysis could significantly simplify the identification process of LWDHP and it was performed in a holistic mode for no less than two compounds of each component herb monitored.
Systematic comparison of metabolic differences of Uncaria rhynchophylla in rat, mouse, dog, pig, monkey and human liver microsomes
TLDR
An efficient strategy comprising a mass defect filter and time-staggered targeted ion lists was established to characterize the metabolites of alkaloids of Uncaria rhynchophylla for the systematic comparison of metabolic differences in rat, mouse, dog, pig, monkey and human liver microsomes, and showed that the mouse livermicrosomes exhibited metabolic behavior most similar to human metabolism of UR alkaloid.
Quantitative analysis of fourteen bufadienolides in Venenum Bufonis crude drug and its Chinese patent medicines by ultra-high performance liquid chromatography coupled with tandem mass spectrometry.
TLDR
This ultra-high performance liquid chromatography coupled with tandem mass spectrometry method could be used for quality assessment of crude drugs and Chinese patent medicines of Venenum Bufonis, and the data could be served as the fundamental basis for drug research and development.
Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity
TLDR
Twelve compounds, including two new aristolochic acid analogues with a formyloxy moiety and 10 known aristolchic acid derivates, were obtained from the roots of Aristolochia contorta using extensive spectroscopic methods, and cytotoxic activity in human proximal tubular cells HK-2 was evaluated by the MTT method.
“Force iteration molecular designing” strategy for the systematic characterization and discovery of new protostane triterpenoids from Alisma Rhizoma by UHPLC/LTQ-Orbitrap-MS
TLDR
A “force iteration molecular designing” strategy is developed, by combing a database-based in-house software for a precursor ion list (PIL) and PIL-triggered collision-induced dissociation-MS2 and high-energy C-trap dissociation -MS2 on an LTQ-Orbitrap mass spectrometer, aiming for the systematic characterization and discovery of new protostane triterpenoids from Alisma Rhizoma.
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