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Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model
- Yu‐Lan Hu, Wang Qi, Feng Han, J. Shao, Jianqing Gao
- BiologyInternational journal of nanomedicine
- 14 December 2011
Embryo exposure to chitosan nanoparticles and ZnO nanoparticles resulted in a decreased hatching rate and increased mortality, which was concentration-dependent, and suggest that the toxicity of biodegradable nanocarriers such as chitotoxicity must be addressed, especially considering the in vivo distribution of these nanoscaled particles.
Potential neurotoxicity of nanoparticles.
Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes.
A protein delivery system: biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres.
Non-viral gene delivery carrier and its three-dimensional transfection system.
Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex.
Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs
Considering the potential in enhanced drug uptake/permeation and facing the limitations, their unique properties make microemulsions a promising vehicle for poorly water-soluble drugs.
Cell Membrane Capsules for Encapsulation of Chemotherapeutic and Cancer Cell Targeting in Vivo.
- Li-hua Peng, Yuanfeng Zhang, Zheng-Wei Mao
- Biology, ChemistryACS applied materials & interfaces
- 17 August 2015
The systematic administration of cancer targeting CMCs loaded with doxorubicin hydrochloride can significantly inhibit tumor growth in mouse xenografts, with significantly reduced toxicity compared to free drug, and suggest that cancer targetingCMCs may have considerable benefits in drug delivery and cancer treatment.
Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration.
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability
PEGylation of adenovirus vectors (Ads) is an attractive strategy in gene therapy, but their entry into cells has been prevented by steric hindrance by polyethylene glycol (PEG) chains.