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Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model
Embryo exposure to chitosan nanoparticles and ZnO nanoparticles resulted in a decreased hatching rate and increased mortality, which was concentration-dependent, and suggest that the toxicity of biodegradable nanocarriers such as chitotoxicity must be addressed, especially considering the in vivo distribution of these nanoscaled particles.
Potential neurotoxicity of nanoparticles.
Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs
Considering the potential in enhanced drug uptake/permeation and facing the limitations, their unique properties make microemulsions a promising vehicle for poorly water-soluble drugs.
Cell Membrane Capsules for Encapsulation of Chemotherapeutic and Cancer Cell Targeting in Vivo.
The systematic administration of cancer targeting CMCs loaded with doxorubicin hydrochloride can significantly inhibit tumor growth in mouse xenografts, with significantly reduced toxicity compared to free drug, and suggest that cancer targetingCMCs may have considerable benefits in drug delivery and cancer treatment.
Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration.
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability
PEGylation of adenovirus vectors (Ads) is an attractive strategy in gene therapy, but their entry into cells has been prevented by steric hindrance by polyethylene glycol (PEG) chains.