Learn More
Differential expression analysis based on “next-generation” sequencing technologies is a fundamental means of studying RNA expression. We recently developed a multi-step normalization method (called TbT) for two-group RNA-seq data with replicates and demonstrated that the statistical methods available in four R packages (edgeR, DESeq, baySeq, and NBPSeq)(More)
RNA-seq is a powerful tool for measuring transcriptomes, especially for identifying differentially expressed genes or transcripts (DEGs) between sample groups. A number of methods have been developed for this task, and several evaluation studies have also been reported. However, those evaluations so far have been restricted to two-group comparisons.(More)
The core circadian oscillator of cyanobacteria consists of three proteins, KaiA, KaiB, and KaiC. This circadian oscillator could be functionally reconstituted in vitro with these three proteins, and therefore has been a very important model in circadian rhythm research. KaiA can bind to KaiC and then stimulate its phosphorylation, but their interaction(More)
Nowadays, people usually depend on augmented reality (AR) systems to obtain an augmented view in a real-world environment. With the help of advanced AR technology (e.g. object recognition), users can effectively distinguish multiple objects of different types. However, these techniques can only offer limited degrees of distinctions among different objects(More)
The R/Bioconductor package, TCC, provides users with a robust and accurate framework to perform differential expression (DE) analysis of tag count data. We recently developed a multi-step normalization method (TbT; Kadota et al., 2012 [3]) for two-group RNA-seq data. The strategy (called DEGES) is to remove data that are potential differentially expressed(More)
—We consider the generalized differential entropy of normalized sums of independent and identically distributed (IID) continuous random variables. We prove that the Rényi entropy and Tsallis entropy of order α (α > 0) of the normalized sum of IID continuous random variables with bounded moments are con-vergent to the corresponding Rényi entropy and Tsallis(More)
  • 1