Jianqi Lian

  • Citations Per Year
Learn More
OBJECTIVE To detect cell frequency and surface markers of peripheral blood CD4⁺;CXCR5⁺;follicular helper T cells (Tfh cells) and analyze the correlation between CD4⁺;CXCR5⁺;Tfh cells and hyperglobulinemia of patients with chronic hepatitis B. METHODS We collected blood samples of 20 HBV infected patients with hyperglobulinemia, 10 chronic HBV infected(More)
OBJECTIVES CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear. MATERIALS AND METHODS We longitudinally investigated the(More)
Pegylated interferon and ribavirin combination therapy is known to be effective in suppressing viral replication in 50-60% of hepatitis C virus (HCV)-infected patients. However, HCV-infected patients often exhibit varied responses to therapy. Therefore, the identification of immunological markers associated with the clinical outcomes of antiviral treatment(More)
Hepatitis C virus (HCV) infection is a global health problem characterized by a high rate of chronic infection, which may in part be due to a defect in myeloid dendritic cells (mDCs). This defect appears to be remedied by treatment with interferon-α (IFN-α) -based antiviral therapies; however, the molecular mechanisms underlying mDC dysfunction in HCV(More)
OBJECTIVE To examine the predictive capacity of the high mobility group box protein-1 (HMGB-1) for disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS). METHODS One hundred and five HFRS patients and 28 controls were studied. The concentrations of HMGB-1 in the blood were measured with a commercially available ELISA. The levels(More)
The objective is to observe the changes in plasma adiponectin (APN) and its predictive capacity for disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS).One hundred and five patients who were treated at our center between October 2011 and December 2012 were randomly enrolled in this study. The patients were divided into a mild-type(More)
Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication effectively and to improve clinical(More)
Dear Editor, The Chinese Ebola treatment unit (China ETU) in Liberia is a field hospital installed by the Central Military Commission of China. Our medical team consisted of military troops and medical staff from local Chinese hospitals. The goal of our team was to fight Ebola hemorrhagic fever in Liberia while also preventing any of the medical team from(More)
OBJECTIVE To determine the effect of internal ribosome entry site (IRES)specific inhibitor RNA (IRNA) on viral gene expression mediated by HCV 5' noncoding region (NCR) in human hepatic carcinoma cell line. METHODS Cotransfection of pCMVNCRluc containing 5'NCR-luc fusion genes and eukaryotic vectors of IRNA into human hepatic carcinoma cells (HHCC) was(More)
BACKGROUND There are limited options for chronic hepatitis B (CHB) patients who have poor responses to adefovir (ADV). OBJECTIVES The aim of this study is to evaluate the effects of adding on telbivudine (LdT) or switching to pegylated interferon alfa-2a (PEG-IFN-α2a) as alternative rescue therapies for patients with poor responses to the initial ADV(More)