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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
The recent approval of a prostate cancer vaccine has renewed hope for anticancer immunotherapies. However, the immunosuppressive tumor microenvironment may limit the effectiveness of currentExpand
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CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer.
The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers, including ovarian cancer, in which they are associated with disease progression at the levels of tumor cellExpand
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H. pylori Escape Host Immunoreaction Through Inhibiting ILK Expression by VacA
Helicobacter pylori (H. pylori) persistently colonizes the gastric mucosa despite a vigorous immune response. Vacuolating cytotoxin secreted by H. pylori has turned out to be a potentExpand
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[Advance in researches on vegetation cover and management factor in the soil erosion prediction model].
Vegetation cover and land management are the main limiting factors of soil erosion, and quantitative evaluation on the effect of different vegetation on soil erosion is essential to land use and soilExpand
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Alcohol Related Violence and Unwanted Sexual Activity on the College Campus
The purpose of this study was to explore the relationships among alcohol consumption sexual assault and rape and nonsexual violence in a college population at a large Northeastern university. AExpand
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AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression
CXCR4 antagonist AMD3100 promoted conversion of Tregs to helper-like cells and reduced PD-1 expression on CD8+ T cells in mesothelioma. The combination of AMD31000 with a mesothelin-targeting immuneExpand
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A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma
BackgroundAlthough dendritic cell (DC) vaccines are considered to be promising treatments for advanced cancer, their production and administration is costly and labor-intensive. We developed a novelExpand
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Therapeutics , Targets , and Chemical Biology CXCL 12 / CXCR 4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer
The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers, including ovarian cancer, in which they are associated with disease progression at the levels of tumor cellExpand
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Vascular normalization: a strategy to recondition the tumor immune microenvironment
Malignant tumors escape from host immune surveillance through multiple mechanisms. Of these, abnormal tumor vasculature and hypoxia are critical in establishing an immunosuppressive tumorExpand