Jianping Yin

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Neuropilins (Nrps) are co-receptors for class 3 semaphorins and vascular endothelial growth factors and important for the development of the nervous system and the vasculature. The extracellular portion of Nrp is composed of two domains that are essential for semaphorin binding (a1a2), two domains necessary for VEGF binding (b1b2), and one domain critical(More)
The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells.(More)
The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor(More)
Receptor-interacting protein (RIP), a Ser/Thr kinase component of the tumor necrosis factor (TNF) receptor-1 signaling complex, mediates activation of the nuclear factor kappaB (NF-kappaB) pathway. RIP2 and RIP3 are related kinases that share extensive sequence homology with the kinase domain of RIP. Unlike RIP, which has a C-terminal death domain, and(More)
This paper proposes a scheme for systematically estimating fingerprint ridge orientation and segmenting fingerprint image by means of evaluating the correctness of the ridge orientation based on neural network. The neural network is used to learn the correctness of the estimated orientation by gradient-based method. The trained network is able to(More)
Extreme learning machine (ELM) has been an important research topic over the last decade due to its high efficiency, easy-implementation, unification of classification and regression, and unification of binary and multi-class learning tasks. Though integrating these advantages, existing ELM algorithms pay little attention to optimizing the choice of(More)
Sensor networks are distributed networks made up of small sensing devices equipped with processors, memory, and short-range wireless communication. They differ from traditional computer networks in that they have resource constraints, unbalanced mixture traffic, data redundancy, network dynamics, and energy balance. Work within wireless sensor networks(More)
Non-immune (naïve) antibody phage libraries have become an important source of human antibodies. The synthetic phage antibody library described here utilizes a single human framework with a template containing human consensus complementarity-determining regions (CDRs). Diversity of the libraries was introduced at select CDR positions using tailored(More)