Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice.
- Jianping Ye, Zhanguo Gao, Jun-yi Yin, Qing He
- BiologyAmerican Journal of Physiology. Endocrinology and…
- 1 October 2007
Experimental evidence thatHypoxia occurs in adipose tissue in obese mice and that adipose hypoxia may contribute to the endocrine alterations is provided and a potential role of hypoxIA in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissues in obesity is suggested.
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
- Zhanguo Gao, Jun-yi Yin, Jianping Ye
- Biology, MedicineDiabetes
- 14 April 2009
Dietary supplementation of butyrate can prevent and treat diet-induced insulin resistance in mouse and the mechanism ofbutyrate action is related to promotion of energy expenditure and induction of mitochondria function.
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
- Zhanguo Gao, D. Hwang, Jianping Ye
- BiologyJournal of Biological Chemistry
- 2002
It is suggested that IRS- 1 is a novel direct substrate for IKK and that phosphorylation of IRS-1 at Ser(312) (and other sites) by IKK may contribute to the insulin resistance mediated by activation of inflammatory pathways.
Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids*
- J. Lee, Jianping Ye, D. Hwang
- BiologyJournal of Biological Chemistry
- 26 September 2003
The results suggest that saturated and polyunsaturated fatty acids reciprocally modulate the activation of TLR4 and its downstream signaling pathways involving MyD88/IRAK/TRAF6 and PI3K/AKT and further suggest the possibility thatTLR4-mediated target gene expression and cellular responses are also differentially modulated by saturated and uns saturated fatty acids.
Efficacy of berberine in patients with type 2 diabetes mellitus.
- Jun-yi Yin, Huili Xing, Jianping Ye
- MedicineMetabolism: Clinical and Experimental
- 1 May 2008
Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210
- Zhanguo Gao, D. Hwang, Jianping Ye
- BiologyJournal of Biological Chemistry
- 13 December 2002
It is suggested that IRS- 1 is a novel direct substrate for IKK and that phosphorylation of IRS-1 at Ser312 (and other sites) by IKK may contribute to the insulin resistance mediated by activation of inflammatory pathways.
Mechanisms of insulin resistance in obesity
- Jianping Ye
- Medicine, BiologyFrontiers in Medicine
- 5 March 2013
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although…
A role of miR‐27 in the regulation of adipogenesis
- Q. Lin, Zhanguo Gao, R. Alarcon, Jianping Ye, Z. Yun
- BiologyThe FEBS Journal
- 1 April 2009
It is demonstrated that the miR‐27 gene family is downregulated during adipogenic differentiation, and represents a new class of adipogenic inhibitors and may play a role in the pathological development of obesity.
Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases*
- Zhanguo Gao, A. Zuberi, M. Quon, Z. Dong, Jianping Ye
- Biology, ChemistryJournal of Biological Chemistry
- 1 July 2003
Aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases, as assessed by phospho-specific antibodies.
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
- Zhanguo Gao, Xiaoying Zhang, Jianping Ye
- Biology, Computer ScienceMolecular Endocrinology
- 1 August 2004
The FFA-signaling pathway that contributes to serine phosphorylation and degradation of IRS-1 in adipocytes and in dietary obese mice is explored and this molecular mechanism may be responsible for insulin resistance associated with hyperlipidemia.
...
...