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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice.
Experimental evidence thatHypoxia occurs in adipose tissue in obese mice and that adipose hypoxia may contribute to the endocrine alterations is provided and a potential role of hypoxIA in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissues in obesity is suggested. Expand
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
It is suggested that IRS- 1 is a novel direct substrate for IKK and that phosphorylation of IRS-1 at Ser(312) (and other sites) by IKK may contribute to the insulin resistance mediated by activation of inflammatory pathways. Expand
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
Dietary supplementation of butyrate can prevent and treat diet-induced insulin resistance in mouse and the mechanism ofbutyrate action is related to promotion of energy expenditure and induction of mitochondria function. Expand
Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids*
The results suggest that saturated and polyunsaturated fatty acids reciprocally modulate the activation of TLR4 and its downstream signaling pathways involving MyD88/IRAK/TRAF6 and PI3K/AKT and further suggest the possibility thatTLR4-mediated target gene expression and cellular responses are also differentially modulated by saturated and uns saturated fatty acids. Expand
Efficacy of berberine in patients with type 2 diabetes mellitus.
It is indicated that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism and homeostasis model assessment of insulin resistance index in type 2 diabetes mellitus patients. Expand
Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin resistance may involve the phosphorylation of serine residues in insulinExpand
Mechanisms of insulin resistance in obesity
  • Jianping Ye
  • Biology, Medicine
  • Frontiers of Medicine
  • 5 March 2013
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance althoughExpand
A role of miR‐27 in the regulation of adipogenesis
It is demonstrated that the miR‐27 gene family is downregulated during adipogenic differentiation, and represents a new class of adipogenic inhibitors and may play a role in the pathological development of obesity. Expand
Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases*
Aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases, as assessed by phospho-specific antibodies. Expand
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
The FFA-signaling pathway that contributes to serine phosphorylation and degradation of IRS-1 in adipocytes and in dietary obese mice is explored and this molecular mechanism may be responsible for insulin resistance associated with hyperlipidemia. Expand