Learn More
Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung(More)
The glucose transporter GLUT1 catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose supply to the brain and other organs. Dysfunctional mutations may lead to GLUT1 deficiency syndrome, whereas overexpression of GLUT1 is a prognostic indicator for cancer. Despite decades of investigation, the structure of GLUT1 remains(More)
Multicast benefits group communications in saving network traffic and improving application throughput, both of which are important for data center applications. However, the technical trend of data center design poses new challenges for efficient and scalable multicast routing. First, the densely connected networks make traditional receiver-driven(More)
Border Gateway Protocol (BGP) plays a critical role in the Internet inter-domain routing reliability. Invalid routes generated by mis-configurations or forged by malicious attacks may hijack the traffic and devastate the Internet routing system, but it is unlikely that a secure BGP can be deployed in the near future to completely prevent them. Although many(More)
The ryanodine receptors (RyRs) are high-conductance intracellular Ca(2+) channels that play a pivotal role in the excitation-contraction coupling of skeletal and cardiac muscles. RyRs are the largest known ion channels, with a homotetrameric organization and approximately 5,000 residues in each protomer. Here we report the structure of the rabbit RyR1 in(More)
PURPOSE Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of lung cancer that urgently needs biomarkers to aid patient management. Here, we undertook the first comprehensive investigation(More)
The goal of data-center networking is to interconnect a large number of server machines with low equipment cost while providing high network capacity and high bisection width. It is well understood that the current practice where servers are connected by a tree hierarchy of network switches cannot meet these requirements. In this paper, we explore a new(More)
The voltage-gated calcium channel Ca(v)1.1 is engaged in the excitation-contraction coupling of skeletal muscles. The Ca(v)1.1 complex consists of the pore-forming subunit α1 and auxiliary subunits α2δ, β, and γ. We report the structure of the rabbit Ca(v)1.1 complex determined by single-particle cryo-electron microscopy. The four homologous repeats of the(More)
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked to ATP binding and dimerization of its two nucleotide binding domains (NBDs). Channel activation also requires phosphorylation of the R domain by poorly understood mechanisms.(More)
Passive testing is a process of detecting faults in a system under test by passively observing its input/output behaviors only without interrupting its normal operations, and proves to be a promising technique for network fault management. We study passive testing of data portions of network protocols and present two algorithms, using an Event-driven(More)