Jianming Gao

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Aberrant expression of Aurora A kinase has been frequently implicated in many cancers and contributes to chromosome instability and phosphorylation-mediated ubiquitylation and degradation of p53 for tumorigenesis. Previous studies showed that p53 is degraded by Kaposi's sarcoma herpesvirus (KSHV) encoded latency-associated nuclear antigen (LANA) through its(More)
Apoptosis of virus infected cells can restrict or dampen full blown virus propagation and this can serve as a protective mechanism against virus infection. Consequently, viruses can also delay programmed cell death by enhancing the expression of anti-apoptotic proteins. Human Bcl-2 is expressed on the surface of the mitochondrial membrane and functions as(More)
A study on marker-assisted selection (MAS) for the rf1 gene, which controls pollen sterility in the sorghum A1 cytoplasm, was conducted on the offspring population of two crosses between a maintainer line, BTx-622, and two sweet sorghum lines, BJ-299 and Lunen-2, to test the effectiveness of the MAS method and develop maintainer lines with sweet and juicy(More)
Traditional Chinese medicinal herbs containing berberine have been historically used to prevent miscarriage. Here, we investigated whether the anti-apoptotic effects of berberine on pre-implantation embryonic development are regulated by miRNA-21. Mouse pronuclear embryos were cultured in medium with or without berberine, and some were then microinjected(More)
This retrospective study investigated the effect of modifications presented in the seventh edition of the American Joint Committee on Cancer (AJCC) Manual for staging esophageal cancer on the characterization of the effectiveness of post-operative chemotherapy and/or radiotherapy, as measured by overall and disease-free survival. The seventh edition of the(More)
Polygalacturonase-inhibiting proteins (PGIPs) are leucine-rich repeat proteins involved in plant defence. The aim of the current study was to isolate the genomic fragment of PGIP genes in alfalfa (Medicago sativa) and to analyse their sequence variation. Four PGIP genes, namely MsPGIP1, MsPGIP2, MsPGIP3 and MsPGIP4, were discovered using the homology(More)
Common leaf spot (CLS), which is caused by Pseudopeziza medicaginis (Lib.) Sacc., is one of the most serious fungal diseases occurring in autotetraploid alfalfa (Medicago sativa) worldwide. Polygalacturonase-inhibiting proteins (PGIPs) are important candidate genes for disease resistance studies in plants. The association between an alfalfa PGIP gene,(More)
Zebra disease, which is caused by Phytophthora nicotianae, is a serious global threat to the main cultivar Agave hybrid No. 11648 (H.11648). This disease requires a long period to obtain anti-P. nicotianae variants by crossbreeding, given that 10 years are needed for this plant to bloom. Therefore, transgenic technology could be useful for the production of(More)
Alligator weed, Alternanthera philoxeroides (Mart.) Grisb, is an amphibious plant with long thick fleshy roots that develop from adventitious roots under drought conditions. To clone differentially-expressed genes from the roots of A. philoxeroides we applied both mRNA differential display and rapid amplification of cDNA ends techniques. A cryptogein-like(More)