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- Amedeo Columbano, Giovanna Maria Ledda-Columbano, +6 authors Joseph D. Locker
- Hepatology
- 2005
We previously observed that Gadd45/MyD118, a member of the Gadd45 family of inducible factors, showed the strongest immediate-early induction common to two distinctive proliferation responses of the… (More)
- Jianmin Tian, Radma Mahmood, Robert Hnasko, Joseph D. Locker
- Cancer research
- 2006
Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it… (More)
- Jianmin Tian, Hai-yan Huang, +4 authors Joseph D. Locker
- The Journal of clinical investigation
- 2011
The growth arrest and DNA damage-inducible 45 (Gadd45) proteins act in many cellular processes. In the liver, Gadd45b (encoding Gadd45β) is the gene most strongly induced early during both… (More)
- Joseph D. Locker, Jianmin Tian, +4 authors Amedeo Columbano
- Hepatology
- 2003
Partial hepatectomy (PH) and some tumor-promoting agents stimulate hepatocyte cell proliferation, but each treatment acts through distinct transcription factors. We compared mouse immediate-early… (More)
The α-fetoprotein (AFP) gene is an important model of developmental gene silencing and neoplastic gene reactivation. Nkx2.8 is a divergent homeodomain factor originally cloned through its binding to… (More)
- Yasuo Hamamori, Babrubahan Samal, Jianmin Tian, Larry Kedes
- The Journal of clinical investigation
- 1995
Anemia is an invariable consequence of end-stage renal failure (ESRF) and recombinant erythropoietin has dramatically improved the quality of life of patients with ESRF. As an alternative approach,… (More)
- Taichiro Nishikawa, Aaron Bell, +11 authors Ira J. Fox
- The Journal of clinical investigation
- 2015
The cause of organ failure is enigmatic for many degenerative diseases, including end-stage liver disease. Here, using a CCl4-induced rat model of irreversible and fatal hepatic failure, which also… (More)
- Yasuo Hamamori, Babrubahan Samal, Jianmin Tian, Larry Kedes
- Human gene therapy
- 1994
A myoblast gene transfer approach was developed to deliver human erythropoietin (EPO) systemically. We created stable, high-level EPO-producing muscle cell clones by transfecting C2 myoblasts with a… (More)
- Joseph T. Bruder, Anthony Appiah, +6 authors Imre Kovesdi
- Human gene therapy
- 2000
Adenovirus vectors expressing gene products that can induce apoptosis have potential utility in gene therapy applications ranging from the treatment of proliferative diseases to transplantation.… (More)