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Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease.
BACKGROUND & AIMS p38Alpha is a mitogen-activated protein kinase that mediates inflammatory responses, but its role in inflammatory bowel disease is unclear. The effects of p38alpha inhibitors have
A Novel lncRNA, LINC00460, Affects Cell Proliferation and Apoptosis by Regulating KLF2 and CUL4A Expression in Colorectal Cancer
TLDR
High LINC00460 expression levels in CRC specimens were correlated with larger tumor size, advanced tumor stage, lymph node metastasis and shorter overall survival, and these findings support a model in which the Linc00460/EZH2/KLF2 and LINC4A/miR-149-5p/CUL4A crosstalk serve as critical effectors in CRC tumorigenesis and progression, suggesting new therapeutic directions in CRC.
Help, hope and hype: ethical considerations of human microbiome research and applications
TLDR
This paper presents a meta-analysis of 148 cases of neglected bowel disease in China over a 25-year period from 1993 to 2002 and shows clear patterns of decline in the number of cases of meningitis and its complications.
Interleukin-25 enhances the capacity of mesenchymal stem cells to induce intestinal epithelial cell regeneration.
TLDR
IL-25 enhances the capacity of MSC to induce intestinal epithelial cell regeneration, and MSC therapy with IL-25 may be a new direction for IBD treatment.
miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.
TLDR
The findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
TLDR
The compositional and network changes in the Gut microbiota in varied CHB stages, suggest the potential contributions of gut microbiota in CHB disease progression.
miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner
TLDR
It is demonstrated that miR-632 promotes GC progression by accelerating angiogenesis in a TFF1-dependent manner and Targeting of miR -632 may be a potential therapeutic approach for GC patients.
Interleukin-25 primed mesenchymal stem cells achieve better therapeutic effects on dextran sulfate sodium-induced colitis via inhibiting Th17 immune response and inducing T regulatory cell phenotype.
TLDR
IL-25 primed MSCs exert improved therapeutic effects on the intestinal inflammation of IBD rats which may be related to the inhibition of Th17 immune response and induction of T Regulatory cell phenotype.
Therapeutic Effects of the In Vitro Cultured Human Gut Microbiota as Transplants on Altering Gut Microbiota and Improving Symptoms Associated with Autism Spectrum Disorder
TLDR
GMT treatment with original and cultured donor gut microbiota significantly ameliorated anxiety-like and repetitive behaviors and improved serum levels of chemokines in an ASD mouse model compared with GMT with original donors’ gut microbiota.
Elevated serum triglyceride and low-density lipoprotein cholesterol promotes the formation of colorectal polyps
TLDR
Combination of the two serum indicators was useful to assess risk of colorectal lesions, maybe more effective in screening hyperplastic polyp, tubular adenoma and advancedAdenoma.
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