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The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
TLDR
This study shows that the Ets family member GABP binds to the Yap promoter and activates YAP transcription, and is an activator of Yap gene expression and a potential therapeutic target for cancers driven by YAP. Expand
Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1.
TLDR
It is demonstrated that Z EB1-AS1 functions as an oncogene in osteosarcoma via epigenetically activating ZEB1 and could be a potential target for osteosARcoma treatment. Expand
Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.
TLDR
Sulforaphane proved to be an effective in vivo inhibitor of acute ethanol-induced fatty liver in mice and possible amelioration of liver injury which occurs under these conditions by chemical activators of Nrf2 is of clinical relevance and worthy of further study. Expand
Long noncoding RNA ZEB 1-AS 1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB 1
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles andExpand
AGT M235T variant is not associated with risk of cancer
TLDR
A meta-analysis demonstrated that AGT M235T variant was not associated with risk of all cancer or various cancers, and well-designed studies with large sample size should be conducted to confirm or refute the non-significant association. Expand
Highly sensitive method for specific, brief, and economical detection of glycoproteins in sodium dodecyl sulfate-polyacrylamide gel electrophoresis by the synthesis of a new hydrazide derivative.
A new hydrazide derivative was synthesized and used for the first time as a specific, brief, and economical probe to selectively visualize glycoproteins in 1-D and 2-D sodium dodecylExpand
Characterization of the wall effect of concrete via random packing of polydispersed superball-shaped aggregates
Abstract On the mesoscopic scale, concrete can be treated as a two-phase composite consisting of aggregates and mortar matrix. The geometrical feature of aggregate particles usually has significantExpand
Catalase ameliorates diabetes‐induced cardiac injury through reduced p65/RelA‐ mediated transcription of BECN1
TLDR
The mechanism responsible for catalase‐mediated protection against heart injury in diabetic mice was investigated, as well as the role of NF‐κB‐p65 in the regulation of autophagic flux and p65‐mediated transcription of BECN1 was investigated. Expand
Expression and clinical significance of latent-transforming growth factor beta-binding protein 2 in primary hepatocellular carcinoma
TLDR
This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to foreign substance abuse. Expand
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