Jianjun Guan

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Gene expression can be controlled in genetically modified cells by employing an inducer/promoter system where presence of the inducer molecule regulates the timing and level of gene expression. By applying the principles of controlled release, it should be possible to control gene expression on a biomaterial surface by the presence or absence of inducer(More)
INTRODUCTION Dilated cardiomyopathy is a major cause of progressive heart failure. Utilization of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However, a major obstacle to stem cell therapy is the delivery and survival of implanted stem cells in the ischemic heart. To address this issue, we have developed a biomimetic(More)
Cardiac tissue regeneration is an integrated process involving both cells and supporting matrix. Cardiomyocytes and stem cells are utilized to regenerate cardiac tissue. Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. Bioactive and biocompatible hydrogels mimicking(More)
Cell therapy with stem/progenitor cells is a new and promising therapeutic approach for many diseases that currently have few satisfying treatments. The prototype of stem cell-based therapy is bone marrow transplanta-tion, which introduces hematopoietic stem cells (HSCs) to restore hematopoiesis after myeloablation in hematologic malignancy such as(More)
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