Jianjun Guan

Learn More
The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested. To assess the contribution of periostin to dermal healing, 6 mm full-thickness excisional wounds were created in the skin of periostin-knockout and wild-type, sex-matched(More)
Gene expression can be controlled in genetically modified cells by employing an inducer/promoter system where presence of the inducer molecule regulates the timing and level of gene expression. By applying the principles of controlled release, it should be possible to control gene expression on a biomaterial surface by the presence or absence of inducer(More)
Cardiac tissue regeneration is an integrated process involving both cells and supporting matrix. Cardiomyocytes and stem cells are utilized to regenerate cardiac tissue. Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. Bioactive and biocompatible hydrogels mimicking(More)
INTRODUCTION Dilated cardiomyopathy is a major cause of progressive heart failure. Utilization of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However, a major obstacle to stem cell therapy is the delivery and survival of implanted stem cells in the ischemic heart. To address this issue, we have developed a biomimetic(More)
Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell(More)
Cell therapy with stem/progenitor cells is a new and promising therapeutic approach for many diseases that currently have few satisfying treatments. The prototype of stem cell-based therapy is bone marrow transplanta-tion, which introduces hematopoietic stem cells (HSCs) to restore hematopoiesis after myeloablation in hematologic malignancy such as(More)
In this paper, a simple and effective attack on a non-blind robust digital watermark method, cocktail watermarking, was proposed. After reviewing the principle of the cocktail watermarking, the paper discovered that the cocktail watermarking scheme can drive a very high false positive probability although with high robustness simultaneously. Furthermore, a(More)
  • 1