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FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
TLDR
It is shown that FTO, as an m6A demethylase, plays a critical oncogenic role in acute myeloid leukemia (AML) and provides profound insights into leukemogenesis and drug response. Expand
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
TLDR
It is demonstrated that specific alterations in miRNA expression distinguish AMLs with common translocations and imply that the deregulation of specific miRNAs may play a role in the development of leukemia with these associated genetic rearrangements. Expand
Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation
TLDR
This work reports the insulin-like growth factor 2 mRNA-binding proteins as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence, and identifies IGF2BPs as an additional class of N6-methyladenosine (m 6A) reader proteins. Expand
Over 20% of human transcripts might form sense-antisense pairs.
TLDR
In this study, a set of very stringent criteria to identify the correct orientation of each human transcript was established and these orientation-reliable transcripts were used to create 26 741 transcription clusters in the human genome. Expand
Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4.
TLDR
The transcription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiation and is also required for generation of germinal center B cells, showing its transient expression in vivo induced the expression of key GC genes including Bcl6 and Aicda. Expand
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
  • S. Mi, J. Lu, +13 authors Jianjun Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 11 December 2007
TLDR
It is shown that expression signatures of as few as two miRNAs could accurately discriminate ALL from AML, and that epigenetic regulation might play an important role in the regulation of expression of miRNAAs in acute leukemias. Expand
miR-21 plays a pivotal role in gastric cancer pathogenesis and progression
TLDR
A potential regulatory pathway in which H. pylori infection upregulates expression of miR-21, which in turn downregulates RECK, and then leads to the development of gastric cancer is suggested. Expand
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
TLDR
The results reveal the SPI1-METTL14-MYB/MYC signaling axis in myelopoiesis and leukemogenesis and highlight the critical roles of METTL14 and m6A modification in normal and malignant hematopoiedis. Expand
Leukaemogenesis: more than mutant genes
TLDR
In table 2 on page 30 of the above article, the reference for miR-196a and miR -196b was mistakenly indicated as reference 103, and this reference has been replaced with references 89, 104 and 108–110. Expand
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
TLDR
While R-2HG accumulated in IDH1/2 mutant cancers contributes to cancer initiation, this work demonstrates anti-tumor effects of 2HG in inhibiting proliferation/survival of FTO-high cancer cells via targeting FTO/m6A/MYC/CEBPA signaling. Expand
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