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Associations Between Hepatitis B Virus Mutations and the Risk of Hepatocellular Carcinoma: A Meta-Analysis
A meta-analysis of case–control and cohort studies to examine HBV PreS, enhancer II (EnhII), basal core promoter (BCP), and precore mutations in relation to the risk of hepatocellular carcinoma (HCC) found these mutations alone and in combination may be predictive for hepatocarcinogenesis. Expand
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, a genome-wide association study in 2,514 chronic HBV carriers followed by a 2-stage validation among 6 independent populations of chronicHBV carriers showed that HCC risk was significantly associated with two independent loci. Expand
Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus-related hepatocellular carcinoma: a two-stage longitudinal clinical study.
  • Jianhua Yin, N. Li, +8 authors G. Cao
  • Medicine
  • Journal of clinical oncology : official journal…
  • 10 October 2013
Although it might not affect the HCC-promoting potential of Ct-HBx, NA treatment is effective in normalizing liver function, decreasing HBV-HCC recurrence, and improving postoperative survival. Expand
Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma
STAT3 SNPs appear to predispose the host with HBV mutations to hepatocarcinogenesis, and this effect may differ in men versus women, which may have applicability in future HCC surveillance algorithms. Expand
Association Between the Various Mutations in Viral Core Promoter Region to Different Stages of Hepatitis B, Ranging of Asymptomatic Carrier State to Hepatocellular Carcinoma
Age, male, abnormal alanine aminotransferase (ALT), T1768A, A1762T/G1764A, and A1846T were independently associated with cirrhosis compared with ASCs and the patients with CHB and HCC, whereas these mutations were inversely associated with HCC compared with the Cirrhosis patients. Expand
Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008-2011.
  • H. Ni, B. Yi, +14 authors G. Cao
  • Medicine
  • Journal of clinical virology : the official…
  • 1 August 2012
HFMD mainly caused by EV71 C4a and CA16 B1 is seriously epidemic in Ningbo, China, and future emphasis should be paid on EV71 immuno-prophylaxis and early identification of severe cases upon the etiological and clinical characteristics. Expand
Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer
Antiandrogen and PARP inhibitor combination therapy may be effective for CRPC patients and suggests that pharmaceutically inducing BRCAness may expand the clinical use of PARP inhibitors to other tumor types. Expand
Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
The rs4938723 variant genotypes in dominant model significantly increased HCC risk in women, compared to female healthy controls and its effect on HCC is significantly affected by the HBV mutations. Expand
Distribution and Hepatocellular Carcinoma–Related Viral Properties of Hepatitis B Virus Genotypes in Mainland China: A Community-Based Study
HBV subgenotypes B2, C1, and C2 are endemic in Mainland China and HBV genotype C exhibits less replication activity in the young and harbors higher frequencies of the HCC-associated mutations than genotype B. Expand
Unique Organizational and Functional Features of the Cytochrome c Maturation System in Shewanella oneidensis
The construction of an entire set of c-type cytochrome mutants utilizing a newly developed att-based mutagenesis approach is completed, which is more effective and efficient than the approach used previously by circumventing the conventional cloning. Expand