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We have reported previously the isolation and genetic characterization of mutations in the gene encoding the largest subunit of yeast RNA polymerase II (RNAPII), which lead to 6-azauracil (6AU)-sensitive growth. It was suggested that these mutations affect the functional interaction between RNAPII and transcription-elongation factor TFIIS because the(More)
Data clustering has been discussed extensively, but almost all known conventional clustering algorithms tend to break down in high dimensional spaces because of the inherent sparsity of the data points. Existing subspace clustering algorithms for handling high-dimensional data focus on numerical dimensions. In this paper, we designed an iterative algorithm(More)
A new neural network architecture (PART) and the resulting algorithm are proposed to find projected clusters for data sets in high dimensional spaces. The architecture is based on the well known ART developed by Carpenter and Grossberg, and a major modification (selective output signaling) is provided in order to deal with the inherent sparsity in the full(More)
Severe acute respiratory syndrome (SARS), a new, highly contagious, viral disease, emerged in China late in 2002 and quickly spread to 32 countries and regions causing in excess of 774 deaths and 8098 infections worldwide. In the absence of a rapid diagnostic test, therapy or vaccine, isolation of individuals diagnosed with SARS and quarantine of(More)
The functions of DNA satellites of centric heterochromatin are difficult to assess with classical molecular biology tools. Using a chemical approach, we demonstrate that synthetic polyamides that specifically target AT-rich satellite repeats of Drosophila melanogaster can be used to study the function of these sequences. The P9 polyamide, which binds the(More)
We develop some techniques to prove analytically the existence and stability of long period oscillations of stem cell populations in the case of periodic chronic myelogenous leukemia. Such a periodic oscillation $p_\infty $ can be analytically constructed when the hill coefficient involved in the nonlinear feedback is infinite, and we show it is possible to(More)