Learn More
OBJECTIVE The objective of this study was to evaluate the effectiveness of the treatment of infected nonunion of tibia and femur by bone transport. MATERIAL AND METHODS We retrospectively reviewed 110 patients with infected nonunion of tibia and femur treated by bone transport. Our study included 92 males and 18 females with a mean age of 38.90 years. The(More)
Postnatal bone marrow contains mesenchymal stem cells (MSCs) that are osteoblast precursors with great therapeutic potential. The oxygen tension in bone marrow is about 1-7% pO2 which is much lower than that of the external environment. The effect of these hypoxic conditions on MSC differentiation is not fully understood. In this study, we show that hypoxia(More)
BACKGROUND Infected nonunion of tibia and femur are common in clinical practice, however, the treatment of these diseases has still been a challenge for orthopaedic surgeons. Ilizarov methods can eradicate infection, compensate bone defects and promote the bone union through progressive bone histogenesis. The objective of this systematic review was to(More)
A novel biomimetic bone scaffold was successfully prepared in this study, which was composed of calcium sulfate hemihydrate (CSH), collagen and nano-hydroxyapatite (nHAC). CSH/nHAC was prepared and observed with scanning electron microscope and rhBMP-2 was introduced into CSH/nHAC. The released protein content from the scaffold was detected using high(More)
Erythropoietin (EPO) has been demonstrated to exert neuroprotective effects on peripheral nerve injury recovery. Though daily intraperitoneal injection of EPO during a long period of time was effective, it was a tedious procedure. In addition, only limited amount of EPO could reach the injury sites by general administration, and free EPO is easily degraded(More)
Negative pressure wound therapy (NPWT) has gained popularity in the management of contaminated wounds as an effective physical therapy, although its influence on the bacteria in the wounds remains unclear. In this study, we attempted to explore the effect of negative pressure conditions on Staphylococcus aureus, the most frequently isolated pathogen during(More)
Various stimulators have been reported to promote MSC osteogenic differentiation via different pathways such as bone morphogenetic protein 9 (BMP9) through influencing COX-2 and miR-548d-5p through targeting peroxisome proliferator-activated receptor-γ (PPARγ). Whether synergistic effects between BMP9 and miR-548d-5p existed in promoting osteogenesis from(More)
In the paper titled " Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury " we have found that, in Figure 1(d), one panel is mistakenly a duplication of the adjacent panel. The upper two western blotting results are identical. According to our inspection of(More)
Immediate hemorrhage control and infection prevention are pivotal for saving lives in critical situations such as battlefields, natural disasters, traffic accidents, and so on. In situ hydrogels are promising candidates, but their mechanical strength is often not strong enough for use in critical situations. In this study, we constructed three hydrogels(More)
STUDY DESIGN A unique case report. OBJECTIVE A three-dimensional (3D) printing technology is proposed for reconstructing multi-level cervical spine (C2-C4) after resection of metastatic papillary thyroid carcinoma in a middle-age female patient. SUMMARY OF BACKGROUND DATA Papillary thyroid carcinoma is a malignant neoplasm with a relatively favorable(More)