Jianguo Wang

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The tyrosine phosphatase SHP2, encoded by PTPN11, is required for the survival, proliferation and differentiation of various cell types. Germline activating mutations in PTPN11 cause Noonan syndrome, whereas somatic PTPN11 mutations cause childhood myeloproliferative disease and contribute to some solid tumours. Recently, heterozygous inactivating mutations(More)
BACKGROUND AND PURPOSE Triple-negative breast cancer (TNBC) presents a high risk breast cancer that lacks the benefit from hormone treatment, chemotherapy is the main strategy even though it exists in poor prognosis. Use of adjuvant radiation therapy, which significantly decreases breast cancer mortality, has not been well described among poor TNBC women.(More)
A linear water-insoluble (1-->3)-beta-D-glucan, coded as GL-IV-I, was isolated from the fruit body of Ganoderma lucidum by extracting with NaOH solution. Its derivatives were prepared by using sulfation, carboxymethylation, hydroxyethylation, hydroxypropylation, and methylation, respectively, and these were labeled as S-GL, CM-GL, HE-GL, HP-GL and M-GL.(More)
Caching is an important optimization in search engine architectures. Existing caching techniques for search engine optimization are mostly biased towards the reduction of random accesses to disks, because random accesses are known to be much more expensive than sequential accesses in traditional magnetic hard disk drive (HDD). Recently, solid state drive(More)
The present paper summarizes the results from a long-term experiment setup in 1980 in the Taihu Lake region, China, to address the yield sustainability, the dynamic changes of soil organic carbon (SOC) storage, and soil fertility in the rice–wheat ecosystem. Treatments in three replicates comprising manure-treated and chemical fertilizer-treated groups (two(More)
Amphotericin B (AmB) is a popular drug frequently applied in the treatment of systemic fungal infections. In the presence of ruthenium (II) as the maker ion, the behavior of AmB to form ion channels in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes were studied by cyclic votammetry, AC impedance(More)
Blood smears and purified trypanosome from freshwater fishes yellow catfish (Pseudobagras fulvidraco) and common carp (Cyprinus carpio) captured from Niushan Lake, Hubei Province were examined to determine whether all of their trypanosomes were Trypanosoma pseudobagri, a species of supposed host specificity and widespread existence across China.(More)
Raw image data offer rich source of information for matching and classification. For simplicity of pattern recognition system design, a sequential approach consisting of sensing, feature extraction and matching is conventionally adopted where each stage transforms a particular component of information relatively independently. The interaction between these(More)