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Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.
Inflammatory reactions in the pathogenesis of atherosclerosis.
The mechanisms of atherogenic lipoproteins in terms of inflammatory reactions associated with hypercholesterolemia are addressed in order to develop novel therapeutic strategies to control, treat and prevent atherosclerosis in the future.
Macrophage Metalloelastase Accelerates the Progression of Atherosclerosis in Transgenic Rabbits
The results suggest that macrophage-derived MMP-12 participates in the progression of atherosclerosis, and may play a pivotal role in the cascade activation of other MMPs, thereby exacerbating extracellular matrix degradation during the progress of Atherosclerosis.
Epidermal Growth Factor Receptor-PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
It is demonstrated that the entry of HSV-1 into neuronal cells induces biphasic remodeling of the actin cytoskeleton and an initial inactivation followed by the subsequent activation of cofilin, a member of theactin depolymerizing factor family that is critical for actin reorganization.
Transgenic rabbits as therapeutic protein bioreactors and human disease models.
Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma).
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.
Expression Systems and Species Used for Transgenic Animal Bioreactors
- Yanli Wang, Sihai Zhao, L. Bai, Jianglin Fan, Enqi Liu
- Biology, MedicineBioMed Research International
- 17 March 2013
It is found that transgenic animals were potentially ideal bioreactors for the synthesis of pharmaceutical protein complexes and rabbits are attractive candidates for the mammary-gland-specific expression of recombinant proteins.
Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions.
- Enqi Liu, M. Morimoto, Jianglin Fan
- Medicine, BiologyJournal of the American Society of Nephrology…
- 1 July 2007
This study provides the first evidence that increased expression of V EGF in glomeruli directly causes the glomerular hypertrophy that is associated with proteinuria, suggesting that VEGF exerts multiple effects on the glomersular pathophysiologic processes.
Overexpression of Hepatic Lipase in Transgenic Mice Decreases Apolipoprotein B-containing and High Density Lipoproteins
Evidence is provided that HL can act as a ligand to remove apoB-containing lipoproteins from plasma and catalytically inactive HL (HL-CAT) in apoE −/−mice is expressed, indicating expression of the active human HL.