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BACKGROUND To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA)-DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population. METHODS A case-control study was performed on the Chinese(More)
The effect of myeloid cell leukemia-1 (Mcl-1) inhibition on apoptosis of peritoneal macrophages in mice infected with Mycobacterium tuberculosis was investigated and the primary signaling pathway associated with the transcriptional regulation of Mcl-1 was identified. Real-time PCR and western blotting indicated that Mcl-1 transcript and protein expression(More)
OBJECTIVE To investigate the gene polymorphism and haplotype distribution characteristics of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 in Han and Uyghur populations from the Xinjiang Uyghur Autonomous Region. METHODS The polymerase chain reaction-sequencing-based typing (PCR-SBT) was applied to analyze the HLA-DRB1, HLA-DQB1 and HLA-DPB1(More)
OBJECTIVE Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients. METHODS A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group. The SNP detection(More)
OBJECTIVE To explore the time-dependent changes in the expressions of ferritin (Fn) and ferroportin (FPN) in macrophages infected with Mycobacterium (M.) tuberculosis of highly virulent strain (H37Rv strain) and Bacillus Calmette-Guerin (BCG) strain. METHODS RAW264.7 macrophages were respectively infected with M. tuberculosis H37Rv strain and BCG strain.(More)
Myeloid cell leukemia-1 (Mcl-1) plays an important role in various cell survival pathways. Some studies indicated that the expression of Mcl-1 was upregulated in host cells during infection with the virulent Mycobacterium tuberculosis strain, H37Rv. The present study was designed to investigate the effect of inhibiting Mcl-1 expression both in vivo and in(More)
OBJECTIVE To identify a novel HLA allele DRB1 * 16:36 from a Uygur woman. METHODS PCR-SBT technology was applied to the extracted DNA for genotyping, and a possible new gene was sequenced by using sequence specific primers and single stranded SBT. This novel allele was compared with known most homologous gene sequences and their difference was analyzed.(More)
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