Jiang-dong Wu

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BACKGROUND To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA)-DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population. METHODS A case-control study was performed on the Chinese(More)
OBJECTIVE Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients. METHODS A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group. The SNP detection(More)
The effect of myeloid cell leukemia-1 (Mcl-1) inhibition on apoptosis of peritoneal macrophages in mice infected with Mycobacterium tuberculosis was investigated and the primary signaling pathway associated with the transcriptional regulation of Mcl-1 was identified. Real-time PCR and western blotting indicated that Mcl-1 transcript and protein expression(More)
OBJECTIVE To investigate the gene polymorphism and haplotype distribution characteristics of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 in Han and Uyghur populations from the Xinjiang Uyghur Autonomous Region. METHODS The polymerase chain reaction-sequencing-based typing (PCR-SBT) was applied to analyze the HLA-DRB1, HLA-DQB1 and HLA-DPB1(More)
OBJECTIVE To investigate the effect of peritoneal macrophage autophagy on immune function in sepsis mice. METHODS Seventy-two male BALB/C mice were intraperitoneally injected with LPS to induce sepsis. The mice were randomly divided into six groups: LPS+2 h, LPS+6 h, LPS+12 h, LPS+24 h and LPS+36 h. LPS with a dose of 10 mg/kg was intraperitoneally(More)
OBJECTIVE To identify a novel HLA allele DRB1 * 16:36 from a Uygur woman. METHODS PCR-SBT technology was applied to the extracted DNA for genotyping, and a possible new gene was sequenced by using sequence specific primers and single stranded SBT. This novel allele was compared with known most homologous gene sequences and their difference was analyzed.(More)
OBJECTIVE To explore the time-dependent changes in the expressions of ferritin (Fn) and ferroportin (FPN) in macrophages infected with Mycobacterium (M.) tuberculosis of highly virulent strain (H37Rv strain) and Bacillus Calmette-Guerin (BCG) strain. METHODS RAW264.7 macrophages were respectively infected with M. tuberculosis H37Rv strain and BCG strain.(More)
Myeloid cell leukemia-1 (Mcl-1) plays an important role in various cell survival pathways. Some studies indicated that the expression of Mcl-1 was upregulated in host cells during infection with the virulent Mycobacterium tuberculosis strain, H37Rv. The present study was designed to investigate the effect of inhibiting Mcl-1 expression both in vivo and in(More)
The temperature is the essential factor that influences the efficiency of anaerobic reactors. During the operation of the anaerobic reactor, the fluctuations of ambient temperature can cause a change in the internal temperature of the reactor. Therefore, insulation and heating measures are often used to maintain anaerobic reactor's internal temperature. In(More)
BACKGROUND An elevated level of homocysteine (Hcy) in the blood is designated hyperhomocysteinaemia (Hhcy) and is regarded as a strong risk factor for the development of atherosclerosis (ATH), although the association remains controversial. Considered to be essential gene expression regulators, micro-RNAs (miRNAs) modulate cardiovascular disease development(More)
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