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Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.
TLDR
For the first time, serum pyrrole-protein adducts were unequivocally detected in a PA-induced HSOS patient, and suchAdducts show a potential to be developed as a biomarker for the assessment of PA- induced HSOS.
Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline.
TLDR
This comparative study provides clear evidence that the generation of the reactive pyrrolic intermediates plays a critical role in PA-induced hepatotoxicity.
Design, synthesis, and structure-activity relationships of haloenol lactones: site-directed and isozyme-selective glutathione S-transferase inhibitors.
TLDR
Understanding of the interaction of GST-pi with haloenol lactone derivatives as site-directed and isozyme-selective inactivators, possibly potentiating cancer chemotherapy is facilitated.
Selective and sensitive platform for function-based screening of potentially harmful furans.
TLDR
The platform has been proven selective, sensitive, effective, and reliable, and ICP MS allows us to estimate the resulting bromine-labeled pyrroles without authentic standards.
Bronchodilator Delivery During Simulated Pediatric Noninvasive Ventilation
TLDR
Albuterol delivery during simulated pediatric NIV was affected by the position of the neBulizer in relation to the expiratory leak valve and the nebulizer's distance from the filter, which may provide a better alternative for medication delivery than those previously used during Pediatrics NIV.
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches
TLDR
Shenxiong glucose injection showed no effects on the enzyme activities of rat CYP1A2, CYP2C19, CyP2D4, CYp2E1, and CYP3A2 but inhibited the enzyme activity of CYP 2C11, and improved the blood concentration of warfarin, suggesting that the dose of warFarin may need be adjusted when co-administrated with SGI.
9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.
TLDR
This is the first study to describe 9-GSH-DHP as a major pyrrolic GSH conjugate of retronecine-type PAs, providing insight into the interactions of dehydro-PAs with biomolecules.
Mechanism-based inactivation of cytochrome P450 3A4 by 4-ipomeanol.
TLDR
4-ipomeanol irreversibly inhibited P450 3A4, and it was characterized as a mechanism-based inactivator of P450 1A2 in human liver microsomes, which facilitates the understanding of the mechanism of bioactivation of 4-IPomeanol by human hepatic enzymes.
Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid.
TLDR
The results indicate that EEA itself does not appear to be hepatotoxic but that the electrophilic intermediate generated by the metabolic activation of the furan ring mediated by cytochromes P450 is responsible for EEA-induced liver injury.
Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin.
TLDR
Isoimperatorin is a mechanism-based inactivator of CYP2B6 and the formation of γ-ketoenal intermediate may be responsible for the enzyme inactivation.
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