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Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity
It is reported that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit their function, suggesting that exosome-mediated transfer of microRNA plays an important role in the regulation of osteoblast activity. Expand
A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells.
The cartilage ECM-derived porous scaffold shows potential as biomaterial for cartilage tissue engineering, and PKH26 fluorescent labeling and in vivo fluorescent imaging can be useful for cell tracking and analyzing cell-scaffold constructs in vivo. Expand
The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes
The signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis are emphasized and integrin-mediated signaling via cell-matrix interaction is emphasized. Expand
miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway
It is shown that miR-214 is up-regulated during osteoclastogenesis from bone marrow monocytes with macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induction, which indicates that mi R-214 plays a critical role in osteoc last differentiation. Expand
Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro
Cell-based therapy has achieved promising functional recovery for peripheral nerve repair. Although Schwann cells (SCs) and bone marrow derived mesenchymal stromal cells (BM-MSCs) are the main cellExpand
Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms
Treatment with h UCMSC-conditioned medium enhanced Schwann cell viability and proliferation, increased nerve growth factor and brain-derived neurotrophic factor expression in Schwann cells, and enhanced neurite growth from dorsal root ganglion explants, suggesting that paracrine action may be a key mechanism underlying the effects of hUCMSCs in peripheral nerve repair. Expand
In vivo cartilage repair using adipose‐derived stem cell‐loaded decellularized cartilage ECM scaffolds
ADSC‐loaded cartilage ECM scaffolds induced cartilage repair tissue comparable to native cartilage in terms of mechanical properties and biochemical components, and showed that the group A levels approached those of normal cartilage. Expand
Prompt peripheral nerve regeneration induced by a hierarchically aligned fibrin nanofiber hydrogel.
The results demonstrate that the AFG creates an instructive microenvironment by mimicking the native fibrin cable as well as the oriented and soft features of nerve ECM to accelerate axonal regrowth, thus showing great promising potential for applications in neural regeneration. Expand
Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration
Function and histomorphometric analysis was used to evaluate 3-month regeneration of the novel cell-supplemented tissue-engineered nerve graft used to bridge a 15-mm-long sciatic nerve gap in rats and found nerve regeneration with BMSC-SCs or ADSC- SCs was comparable to that with autografting and Schwann cells alone and better than that with acellular nerve allografts alone. Expand
Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
A novel PLGA-based polymeric nanocarrier co-encapsulated with doxorubicin (DOX) and magnetic Fe3O4 nanoparticles (MNPs) using a single emulsion evaporation method that may provide a new modality for developing an effective drug delivery system. Expand