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The molecular events that modulate chromatin structure during skeletal muscle differentiation are still poorly understood. We report in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased when myoblasts differentiate into myotubes and is required for skeletal muscle development, expression of muscle contractile proteins, and(More)
The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) is a protein with unclear functions. We report that C9ORF72 is a(More)
Human genetic studies have established a link between a class of centrosome proteins and microcephaly. Current studies of microcephaly focus on defective centrosome/spindle orientation. Mutations in WDR62 are associated with microcephaly and other cortical abnormalities in humans. Here we create a mouse model of Wdr62 deficiency and find that the mice(More)
Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA (miRNA) processing, leads to rapidly progressive DCM,(More)
Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, and proliferation. However, how Pax7 is regulated during the transition from proliferating satellite cells to differentiating myogenic(More)
microRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that negatively regulate gene expression post-transcriptionally. The emerging field of miRNA biology has begun to unravel roles for these regulatory molecules in a range of biological functions, including cardiac and skeletal muscle development, as well as in muscle-related disease(More)
BACKGROUND MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ~22 nucleotides in length. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) of their regulatory target mRNAs. Recent work has begun to reveal roles for miRNAs in a wide range of biological processes, including cell(More)
We present a new approach to harvesting a large-scale, high quality image-caption corpus that makes a better use of already existing web data with no additional human efforts. The key idea is to focus on Déjà Image-Captions: naturally existing image descriptions that are repeated almost verbatim – by more than one individual for different images. The(More)
We study hierarchical classification of products in electronic commerce, classifying a text description of a product into one of the leaf classes of a tree-structure taxonomy. In particular, we investigate two essential problems, performance evaluation and learning, in a synergistic way. Unless we know what is the appropriate performance evaluation metric(More)
Why do certain combinations of words such as " disadvantageous peace " or " metal to the petal " appeal to our minds as interesting expressions with a sense of creativity, while other phrases such as " quiet teenager " , or " geometrical base " not as much? We present statistical explorations to understand the characteristics of lexical compositions that(More)