Jianfeng Yang

Learn More
BACKGROUND Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated to play roles in growth, adaptation and homeostasis in all eukaryotes, with perturbation of(More)
It is unknown how the composition and structure of DNA within the cell affect spontaneous mutations. Theory suggests that in eukaryotic genomes, nucleosomal DNA undergoes fewer C→T mutations because of suppressed cytosine hydrolytic deamination relative to nucleosome-depleted DNA. Comparative genomic analyses and a mutation accumulation experiment showed(More)
Cloud computing, a rapidly developing information technology, has aroused the concern of the whole world. Cloud computing is Internet-based computing, whereby shared resources, software and information, are provided to computers and devices on-demand, like the electricity grid [1]. Cloud computing is the product of the fusion of traditional computing(More)
Many theoretical models of reading assume that different writing systems require different processing assumptions. For example, it is often claimed that print-to-sound mappings in Chinese are not represented or processed sub-lexically. We present a connectionist model that learns the print to sound mappings of Chinese characters using the same functional(More)
Although its precise functional contribution to reading remains unclear, there is broad consensus that an activity in the left mid-fusiform gyrus is highly sensitive to written words and word-like stimuli. In the current study, we take advantage of a particularity of the Chinese writing system in order to manipulate word-likeness parametrically, from real(More)
Charge plays an important role in protein-protein interactions. In the case of excessively charged proteins, their electrostatic potentials contribute to the processes of recognition and binding with other proteins or ligands. We present an automated computational framework for determining the contribution of each charged amino acid to the electrostatic(More)
AIMS Based on a case-control study, we investigated the relationship between +869T/C and +915G/C gene polymorphisms in transforming growth factor-beta1 (TGF-beta1), protein levels and essential hypertension (EH) in the Kazakh and Han Chinese populations selected from the Boertonggu countryside of Shawan region in the Xinjiang Uygur Autonomous Region of(More)
Functional magnetic resonance imaging (fMRI) studies of speech sound categorization often compare conditions in which a stimulus is presented repeatedly to conditions in which multiple stimuli are presented. This approach has established that a set of superior temporal and inferior parietal regions respond more strongly to conditions containing stimulus(More)
The complement system is an integral part of the innate immune system that participates in the clearance of pathogens from the body. The association between complement protein fragment C3d and B or T cell-receptor complement receptor (CR) 2 represents a crucial link between innate and adaptive immunities. The goal of this study is to predict association(More)
Cognitive models of reading all assume some division of labor among processing pathways in mapping among print, sound and meaning. Many studies of the neural basis of reading have used task manipulations such as rhyme or synonym judgment to tap these processes independently. Here we take advantage of specific properties of the Chinese writing system to test(More)