Jianfei Lu

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The term mitophagy is coined to describe the selective removal of mitochondria by autophagy but the process itself is still contentious, especially in the early period following subarachnoid hemorrhage (SAH). In the present study, we investigated the role of mitophagy following 48h after SAH injury in rats. Specifically evaluating whether mitophagy, through(More)
UNLABELLED Ganglioside GM1, which is particularly abundant in the central nervous system (CNS), is closely associated with the protection against several CNS disorders. However, controversial findings have been reported on the role of GM1 following ischemic stroke. In the present study, using a rat middle cerebral artery occlusion (MCAO) model, we(More)
Human umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not well understood. This study evaluated the effects of hyperacute intraarterial transplantation of hUCB mononuclear cells (MNCs) on cerebrovascular(More)
Rhynchophylline (Rhy) has been demonstrated protective effects on some neurological diseases. However, the roles of Rhy in the subarachnoid hemorrhage (SAH) are still to be cleared. In the present study, the effects of Rhy on attenuation of early brain injury (EBI) after SAH have been evaluated. The adult male Sprague-Dawley rats (280-300g) were used to(More)
Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ(More)
Loss of von Hippel-Lindau tumor suppressor protein (VHL) or hypoxia results in nuclear relocalization of PDCD5 and subsequent mouse double minute 2 homolog (Mdm2) degradation. Thus, VHL may involved in the PDCD5 mediated apoptosis and autophagy after MCAO. In the present study, using PDCD5 knockout (PDCD5-/-) mice, we aimed to demonstrate that knockout of(More)
Constraints on the molecular gas content of galaxies at high redshift are crucial to further our understanding of star formation and galaxy evolution through cosmic times, as molecular gas is the fuel for star formation. Since its initial detection at large cosmic distances almost two decades ago, studies of molecular gas in the early universe have come a(More)
At high redshifts, the observed galaxy mass functions are fit reasonably well by a Schecter function, having an exponential falloff on the high mass end, much like the mass functions for low-z galaxies. This is in stark contrast to the IR luminosity function which traces star formation activity is best fit with a power-law falloff at high luminosities. In(More)
Diffusion-weighted arterial spin labeling magnetic resonance imaging has recently been proposed to quantify the rate of water exchange (Kw) across the blood-brain barrier in humans. This study aimed to evaluate the blood-brain barrier disruption in transient (60 min) ischemic stroke using Kw magnetic resonance imaging with cross-validation by dynamic(More)
We present results on the infrared properties of Lyman α emitters. At z=0.3 we demonstrate that our sample of 50 GALEX-identified emitters possess the same extinction properties as similarly ultraviolet-bright galaxies at the same redshift. The AGN fraction for these z=0.3 sources is low, 10-20%, and they show no correlation between Lyα flux and total(More)
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