Jianchen Zhang

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BACKGROUND Interest in lycopene metabolism and regulation is growing rapidly because accumulative studies have suggested an important role for lycopene in human health promotion. However, little is known about the molecular processes regulating lycopene accumulation in fruits other than tomato so far. RESULTS On a spontaneous sweet orange bud mutant with(More)
SUMMARY In this paper, we propose a stochastic dynamic local search (SDLS) method for Multiple-Valued Logic (MVL) learning by introducing stochastic dynamics into the traditional local search method. The proposed learning network maintains some trends of quick descent to either global minimum or a local minimum, and at the same time has some chance of(More)
SUMMARY This paper describes an improved local search method for synthesizing arbitrary Multiple-Valued Logic (MVL) function. In our approach , the MVL function is mapped from its algebraic presentation (sum-of-products form) on a multiple-layered network based on the functional completeness property. The output of the network is evaluated based on two(More)
As a novel optimization technique, chaos has gained much attention and some applications during the past decade. For a given energy or cost function, by following chaotic ergodic orbits, a chaotic dynamic system may eventually reach the global optimum or its good approximation with high probability. To enhance the performance of the local search method(More)
SUMOylation, as a post-translational modification of proteins, plays essential regulatory roles in a variety of pathological conditions. In the dynamic process of SUMOylation and deSUMOylation, SENPs (SUMO-specific proteases), in charge of deconjugation of SUMO (small ubiquitin-related modifier) from substrate proteins, have recently been found to be(More)
The small ubiquitin-related modifier (SUMO)-specific proteases (SENPs) catalyze the deconjugation of SUMO from their substrate proteins. SENP1 which is the most studied isoform is closely related to many cancers such as prostate cancer and colon cancer, thus representing a potential therapeutic target for cancer treatment. In the present study, we(More)
With the introduction of a diisopropyloxyphosphoryl (DIPP) group at the N-terminus of amino acids, the signal response in electrospray ionization mass spectrometry can be enhanced by 10-100-fold in positive mode and even more in negative mode. An enhancement of proton affinity due to the N-terminal DIPP derivatization was considered to be responsible for(More)
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