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The first synthetic route to furostan saponins
Abstract 26- O -β- d -Glucopyranosyl-22-methoxy-25( R )-furost-5-en-3β-ol 3- O -β- d -glucopyranoside is synthesized from diosgenin in 11 steps and 26% overall yield. The present synthetic route… Expand
Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.
Many compounds within this piperazine series of [1,2,4]triazolo[1,5-a]triazine have now been shown to have good oral bioavailability in the rat, with some as high as 89% (compound 35). Expand
A novel cleavage of allyl protection
Abstract A novel, efficient, and mild cleavage of allyl protection is developed employing perfluoroalkylation and subsequent elimination.
A Novel and Efficient Deprotection of the Allyl Group at the Anomeric Oxygen of Carbohydrates
A facile preparation of peracylated alpha-aldopyranosyl chlorides with thionyl chloride and tin tetrachloride.
Aldopyranose peracetates react with thionyl chloride and tin tetrachloride, producing the corresponding peracylated aldopyranosyl chlorides in very good to excellent yields (88-100%) with exclusive… Expand
Synthesis of 2-Quinolinones through Palladium(II) Acetate Catalyzed Cyclization of N-(2-Formylaryl)alkynamides
A Pd(OAc)2-catalyzed cyclization of N-(2-formylaryl)alkynamides initiated by the oxypalladation of alkynes was developed. The method provides a new approach for the efficient and atom-economical… Expand
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.
- C. Vu, W. Kiesman, +8 authors Jianbo Zhang
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2 November 2006
Modifications to 14 showed that the bridgehead hydroxyl group could be replaced with a propionic acid without a significant loss in binding affinity or in vivo activity and this level of efficacy is comparable to that of BG9928. Expand
A concise synthesis of nornitidine via nickel- or palladium-catalyzed annulation
A concise method to synthesize benzo[c]phenanthridine alkaloid, nornitidine, was developed utilizing nickel- or palladium-catalyzed iminoannulation of an internal alkyne. The advantages of this… Expand
Eco-friendly synthesis of 5-hydroxymethylfurfural (HMF) and its application to the Ferrier-rearrangement reaction
ABSTRACT 5-Hydroxymethylfurfural was conveniently synthesized by dehydration of D-fructose in a good yield. To further build bioactive derivatives from 5-hydroxymethylfurfural, 2,3-unsaturated… Expand
H2SO4-SiO2: Highly Efficient and Reusable Catalyst for per-O-Acetylation of Carbohydrates Under Solvent-Free Conditions
Sulfuric acid immobilized on silica gel (H2SO4-SiO2) was used as an efficient promoter for per-O-acetylation of carbohydrates with acetic anhydride under solvent-free conditions. The substrates… Expand