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Review for carrageenan-based pharmaceutical biomaterials: favourable physical features versus adverse biological effects.
TLDR
A review of the latest literature on the development of CRG-based pharmaceutical vehicles and the perspective of using CRG for broader biomedical applications focuses on how current strategies exploit the unique gelling mechanisms, strong water absorption and abundant functional groups of the three major CRG varieties. Expand
Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice
TLDR
It is shown that D 6D activity is upregulated during melanoma and lung tumor growth and that suppressing D6D activity, either by RNAi knockdown or a specific D6d inhibitor, dramatically reduces tumor growth. Expand
Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells
TLDR
As potential adjuvants to chemotherapy for non–small cell lung cancer, COP and BER increase ROS production, reduce MDR, and enhance the inhibitory effects of chemotherapeutic agents on A549 cell growth. Expand
Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root
TLDR
Box-Behnken design was used to optimize the experimental conditions for ultrasound-assisted extraction of polysaccharides from Rhynchosia minima root and showed that poly Saccharide fractions from PRM have the potential to be developed as natural antioxidants and anticancer ingredients for the food and pharmaceutical industries. Expand
Transgenic n-3 PUFAs enrichment leads to weight loss via modulating neuropeptides in hypothalamus
TLDR
The results indicate that fat-1 gene or n-3 PUFAs participates in regulation of body weight, and the mechanism of this phenomenon involves the expression of appetite neuropeptides and lipoproteins infat-1 transgenic mice. Expand
Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor.
TLDR
The results show that a supramolecular approach could lead to a new preventive and/or therapeutic strategy for counteracting the deleterious effects of some neurotoxins leading to neurodegeneration. Expand
UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar
TLDR
Findings indicated that other herbs in AGNH could have a protective effect against cinnabar- and realgar-induced hepatic and renal damage via modulating the disordered homeostasis of the glycerophospholipid, arachidonic acid, linoleic acid, ether lipid, and sphingolipids metabolism. Expand
Simultaneous determination of seven phenolic acids in three Salvia species by capillary zone electrophoresis with β-cyclodextrin as modifier.
TLDR
Under the optimum conditions, samples of Danshen and related medicinal plants were analyzed using the developed method with high separation efficiency, indicating the good repeatability of the proposed method. Expand
Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo
TLDR
The results revealed that OtoN treatment may attenuate PTZ-induced morphology changes, cell death, LDH efflux in embryonic neuronal cells of C57BL/6J mice, and convulsive behavior in zebrafish, and the first investigation of the neuroprotective effects of Oto N, which might be developed as a novel antiepileptic drug. Expand
Cyanidin-3-o-β-Glucoside Induces Megakaryocyte Apoptosis via PI3K/Akt- and MAPKs-Mediated Inhibition of NF-κB Signalling.
TLDR
The data indicate that Cy-3-g induces megakaryocyte apoptosis via the inhibition of NF-κB signalling, which may play important roles in regulating thrombopoiesis. Expand
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