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BACKGROUND The radial artery has been increasingly used in CABG. However, angiographic outcome data have been limited. METHODS AND RESULTS We reviewed all coronary angiography procedures from February 1996 to October 2001 and selected patients with a radial artery bypass graft. Angiographic outcomes were divided into groups as (1) occluded, (2) severe(More)
Multiple pathways are responsible for transducing mechanical and hormonal stimuli into changes in gene expression during heart failure. In this study our goals were (i) to develop a sound statistical method to establish a comprehensive cutoff point for identification of differentially expressed genes, (ii) to identify a gene expression fingerprint for heart(More)
In electroporation, an electric field transiently permeabilizes the cell membrane to gain access to the cytoplasm, and to deliver active agents such as DNA, proteins, and drug molecules. Past work suggests that the permeabilization is caused by the formation of aqueous, conducting pores on the lipid membrane, which are also known as electropores. The(More)
A numerical study of electroporation-mediated molecular delivery is presented. The model consists of the Nernst-Planck equations for species transport, coupled with an asymptotic Smoluchowski equation for membrane permeabilization. The transfer of calcium ions into a Chinese Hamster Ovary cell is simulated. The results reveal important physical insights.(More)
BACKGROUND There is increasing interest in the role of valve repair for patients with isolated severe aortic regurgitation. Those with bicuspid aortic valves are suggested as most suitable for repair. Morphologic features of these valves that suggest feasibility of repair are not well defined. METHODS Perioperative echocardiograms on 132 consecutive(More)
Social Delay Tolerant Networks (SDTNs) are a special kind of Delay Tolerant Network (DTN) that consists of a number of mobile devices with social characteristics. The current research achievements on routing algorithms tend to separately evaluate the available profit for each prospective relay node and cannot achieve the global optimal performance in an(More)
BACKGROUND Selective atrioventricular nodal (AVN) vagal stimulation (AVN-VS) has emerged as a novel strategy for ventricular rate (VR) control in atrial fibrillation (AF). Although AVN-VS preserves the physiological ventricular activation sequence, the resulting rate is slow but irregular. In contrast, AVN ablation with pacemaker implantation produces(More)
The ACUTE trial randomly assigned patients who had atrial fibrillation (AF) of >2 days' duration to a transesophageal echocardiographically guided or a conventional strategy before cardioversion. In the 571 patients who underwent transesophageal echocardiography (TEE) in the ACUTE trial, we assessed the relative predictive value of baseline data derived by(More)
The transport mechanisms in electroporation-mediated molecular delivery are experimentally investigated and quantified. In particular, the uptake of propidium iodide (PI) into single 3T3 fibroblasts is investigated with time- and space-resolved fluorescence microscopy, and as a function of extracellular buffer conductivity. During the pulse, both the peak(More)