Jianbin Huang

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Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats). Hpo phosphorylates and activates Wts, which in turn, through unknown(More)
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout postnatal life. In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately antagonizes the transcriptional coactivator Yorkie (Yki).(More)
The coordination between cell proliferation and cell death is essential to maintain homeostasis within multicellular organisms. The mechanisms underlying this regulation are yet to be completely understood. Here, we report the identification of hippo (hpo) as a gene that regulates both cell proliferation and cell death in Drosophila. hpo encodes a Ste-20(More)
Community detection is an important task for mining the structure and function of complex networks. Generally, there are several different kinds of nodes in a network which are cluster nodes densely connected within communities, as well as some special nodes like hubs bridging multiple communities and outliers marginally connected with a community. In(More)
Community detection is an important task for mining the structure and function of complex networks. Many pervious approaches are difficult to detect communities with arbitrary size and shape, and are unable to identify hubs and outliers. A recently proposed network clustering algorithm, SCAN, is effective and can overcome this difficulty. However, it(More)
The investigation of community structure in networks has aroused great interest in multiple disciplines. One of the challenges is to find local communities from a starting vertex in a network without global information about the entire network. Many existing methods tend to be accurate depending on a priori assumptions of network properties and predefined(More)
What is happening around the world? When and where? Mining the geo-tagged Twitter stream makes it possible to answer the above questions in real-time. Although a single tweet can be short and noisy, proper aggregations of tweets can provide meaningful results. In this paper, we focus on hierarchical spatio-temporal hashtag clustering techniques. Our system(More)
RATIONALE Loss of fibulin-4 during embryogenesis results in perinatal lethality because of aneurysm rupture, and defective elastic fiber assembly has been proposed as an underlying cause for the aneurysm phenotype. However, aneurysms are never seen in mice deficient for elastin, or for fibulin-5, which absence also leads to compromised elastic fibers. (More)
OBJECTIVE this study aimed to correlate magnetic resonance (MR) findings and discography with pain response at provocative discography in patients with low back pain. METHODS ninety-three patients who underwent MR imaging of the lumbar spine and subsequent provocation discography as part of a clinical evaluation of low back pain were enrolled in the study.(More)
Joint replacement is the most effective treatment for end-stage osteoarticular disease. However, macrophage-mediated aseptic loosening of joint prosthesis severely hampers the clinical effects of joint replacement. Until now, the mechanism by which macrophages regulate the secretion of inflammatory cytokines after particle stimulation is not clear. It is(More)