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Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout postnatal life. In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately antagonizes the transcriptional coactivator Yorkie (Yki).(More)
Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats). Hpo phosphorylates and activates Wts, which in turn, through unknown(More)
The coordination between cell proliferation and cell death is essential to maintain homeostasis within multicellular organisms. The mechanisms underlying this regulation are yet to be completely understood. Here, we report the identification of hippo (hpo) as a gene that regulates both cell proliferation and cell death in Drosophila. hpo encodes a Ste-20(More)
Community detection is an important task for mining the structure and function of complex networks. Generally, there are several different kinds of nodes in a network which are cluster nodes densely connected within communities, as well as some special nodes like hubs bridging multiple communities and outliers marginally connected with a community. In(More)
Community detection is an important task for mining the structure and function of complex networks. Many pervious approaches are difficult to detect communities with arbitrary size and shape, and are unable to identify hubs and outliers. A recently proposed network clustering algorithm, SCAN, is effective and can overcome this difficulty. However, it(More)
The investigation of community structure in networks has aroused great interest in multiple disciplines. One of the challenges is to find local communities from a starting vertex in a network without global information about the entire network. Many existing methods tend to be accurate depending on a priori assumptions of network properties and predefined(More)
Clustering is an important technique for mining the intrinsic community structures in networks. The density-based network clustering method is able to not only detect communities of arbitrary size and shape, but also identify hubs and outliers. However, it requires manual parameter specification to define clusters, and is sensitive to the parameter of(More)
What is happening around the world? When and where? Mining the geo-tagged Twitter stream makes it possible to answer the above questions in real-time. Although a single tweet can be short and noisy, proper aggregations of tweets can provide meaningful results. In this paper, we focus on hierarchical spatio-temporal hashtag clustering techniques. Our system(More)
Groupers (Epinephelus spp.) are economically important fish species in Southeast Asian aquaculture. Vibriosis caused by Vibro spp. is one of the severe bacterial diseases that devastate the grouper aquaculture industry. Probiotics have been reported to show the potential to enhance fish immunity and to antagonize pathogens. In our previous study, a lactic(More)
RATIONALE Loss of fibulin-4 during embryogenesis results in perinatal lethality because of aneurysm rupture, and defective elastic fiber assembly has been proposed as an underlying cause for the aneurysm phenotype. However, aneurysms are never seen in mice deficient for elastin, or for fibulin-5, which absence also leads to compromised elastic fibers. (More)