JianKui Chen

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We discuss here a new approach to detecting hepatotoxicity by employing concentration changes of liver-specific blood proteins during disease progression. These proteins are capable of assessing the behaviors of their cognate liver biological networks for toxicity or disease perturbations. Blood biomarkers are highly desirable diagnostics as blood is easily(More)
Liver-specific microRNA-122 (miR-122) is involved in the replication of hepatitis C virus (HCV) and its potential as a target for antiviral intervention was recently assessed. However, the use of circulating miR-122 in the evaluation of liver function has never been reported. In the present study, changes of serum miRNA levels were first evaluated in acute(More)
Enterococcus faecalis is increasingly becoming an important nosocomial infection opportunistic pathogen. E. faecalis can easily obtain drug resistance, making it difficult to be controlled in clinical settings. Using bacteriophage as an alternative treatment to drug-resistant bacteria has been revitalized recently, especially for fighting drug-resistant(More)
Escherichia coli is an important opportunistic pathogen. It can cause sepsis and severe infection. The application of lytic bacteriophages to treat infectious diseases is an alternative to antibiotics. A lytic Escherichia coli phage, designated IME-EC2, was isolated from hospital sewage. Transmission electron microscopy revealed that IME-EC2 to be a member(More)
The genus ‘T4-like viruses’ includes many lytic bacteriophages that infect a wide range of bacteria, including many pathogenic ones. These phages are composed of doublestranded DNA genome held in an icosahedral head attached to a contractile tail with fibers. Sequence analysis of the major head gene (g23) has suggested that members of genus ‘T4-like(More)
T4 phage is a model species that has contributed broadly to our understanding of molecular biology. T4 DNA replication and packaging share various mechanisms with human double-stranded DNA viruses such as herpes virus. The literature indicates that T4-like phage genomes have permuted terminal sequences, and are generated by a DNA terminase in a(More)
Stenotrophomonas maltophilia bacteriophage IME13 is a virulent phage with a large burst size, exceeding 3,000, much larger than that of any other stenotrophomonas phage reported before. It showed effective lysis of Stenotrophomonas maltophilia. Additionally, the phage IME13 developed at least three obviously different sizes of plaques when a single plaque(More)
Tension control and precise conveyance in web-handling machines are critical to ensure product quality. This paper is focused on actualizing a hybrid control method of tension and position for a discontinuous web transport system. First, the simplified algebraic dynamical models of the unwind/rewind section and feed section are presented, which plays an(More)
Antibiotic-resistant opportunistic pathogens have become a serious concern in recent decades, as they are increasingly responsible for hospital-acquired infections. Here, we describe quinolone-resistant Delftia sp. strain 670, isolated from the sputum of a patient who died from severe pulmonary infection. The draft genome sequence of this strain was(More)
The application of an LQG controller in antenna servo system is presented in this work, using Nanshan 25-m antenna of Xinjiang Astronomical Observatory. A linear quadratic optimal controller is designed, based on establishing controlled object model and according to the quadratic performance index. Meanwhile, taking into account the actual situation of the(More)