Jian-zhong Sun

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BACKGROUND AND PURPOSE Several magnetic resonance imaging (MRI) techniques are being exploited to measure brain iron levels increasingly as iron deposition has been implicated in some neurodegenerative diseases. However, there remains no unified evaluation of these methods as postmortem measurement isn't commonly available as the reference standard. The(More)
AIM To study the relationship between nm23H1 gene genetic instability and its clinical pathological characteristics in Chinese digestive system cancer patients. METHODS Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) was used to analyze the microsatellite instability (MSI) and loss of heterozygosity (LOH). Immunohistochemistry(More)
AIM To compare the features of biochemical metabolic changes detected by hepatic phosphorus-31 magnetic resonance spectroscopy ((31)P MRS) with the liver damage score (LDS) and pathologic changes in rabbits and to investigate the diagnostic value of (31)P MRS in acute hepatic radiation injury. METHODS A total of 30 rabbits received different radiation(More)
Leiomyomatosis peritonealis disseminata (LPD) is a rare condition in females. We report a case of pancreatic implantation with malignant transformation of LPD in a man. A 42-year-old man presented with a 16-month history of persistent pain in the right upper abdomen with dorsolumbar radiating pain and weight loss. Spiral computed tomography revealed diffuse(More)
Background. The clinical applications of hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) remain to be difficult because the changes of phosphates between normal hepatic tissues and pathological tissues are not so obvious, and furthermore, up to now there is few literature on hepatocyte-targeted 31P MRS. Materials and Methods. The ATP-loaded(More)
OBJECTIVE To evaluate the changes of phosphorus metabolites in leukemic infiltration of liver (LIL) with two-dimensional chemical shift imaging(2D CSI)(31)phosphorus MR spectroscopy ((31)P MRS). METHODS Fifteen patients with LIL and 12 healthy subjects (control group) were scanned with liver 2D CSI(31)P MRS by a 1.5T MR Scanner(Sonata, Siemens(More)
A pathogenetic role of OH in myocardial stunning has been inferred from the protective effects of OH scavengers and iron chelators. However, conclusive demonstration of the OH radical hypothesis of myocardial stunning requires direct verification of three major, but still unproven, assumptions: (1) OH is produced in the stunned myocardium in vivo; (2)(More)
OBJECTIVE To investigate the biochemical metabolic changes detected by phosphorus-31 MR spectroscopy ((31)P MRS) with pathologic changes in the liver of fasting rabbits. METHODS A total of 22 rabbits were under the starvation up to death to establish animal models. Hepatic (31)P MRS was performed in different period of 10 rabbits including normal(More)
OBJECTIVE To assess brush sign (BS) on susceptibility-weighted imaging (SWI) in prediction of hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS) after intravenous thrombolysis(IVT). METHODS Patients with acute cerebral ischemic stroke, who had major cerebral artery occlusion (internal carotid artery, middle cerebral artery M1 and(More)