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Regulation of FAS Ligand Expression during Activation-Induced Cell Death in T Cells by p38 Mitogen-Activated Protein Kinase and C-Jun Nh2-Terminal Kinase
Activation-induced cell death (AICD) is a mechanism of peripheral T cell tolerance that depends upon an interaction between Fas and Fas ligand (FasL). Although c-Jun NH2-terminal kinase (JNK) and p38Expand
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Cancer stem cells: the lessons from pre-cancerous stem cells
  • Jian-xin Gao
  • Biology, Medicine
  • Journal of cellular and molecular medicine
  • 5 December 2007
•  Introduction •  Stem cells and cancer stem cells ‐  Properties of stem cells ‐  Cancer stem cell hypothesis •  Development of pre‐cancerous and cancer stem cells ‐  Origin of pre‐cancerous stemExpand
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Identification of Piwil2-Like (PL2L) Proteins that Promote Tumorigenesis
PIWIL2, a member of PIWI/AGO gene family, is expressed in the germline stem cells (GSCs) of testis for gametogenesis but not in adult somatic and stem cells. It has been implicated to play anExpand
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Precancerous Stem Cells Can Serve As Tumor Vasculogenic Progenitors
Tumor neo-vascularization is critical for tumor growth, invasion and metastasis, which has been considered to be mediated by a mechanism of angiogenesis. However, histopathological studies haveExpand
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Perinatal Blockade of B7-1 and B7-2 Inhibits Clonal Deletion of Highly Pathogenic Autoreactive T Cells
A number of in vitro studies have suggested that costimulatory molecules B7-1 and B7-2 and their receptor CD28 can promote clonal deletion, and limited in vivo studies have indicated that CD28 isExpand
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Germline Stem Cell Gene PIWIL2 Mediates DNA Repair through Relaxation of Chromatin
DNA damage response (DDR) is an intrinsic barrier of cell to tumorigenesis initiated by genotoxic agents. However, the mechanisms underlying the DDR are not completely understood despite of extensiveExpand
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Clonal Deletion of Simian Virus 40 Large T Antigen-Specific T Cells in the Transgenic Adenocarcinoma of Mouse Prostate Mice: An Important Role for Clonal Deletion in Shaping the Repertoire of T Cells
In addition to their overexpression in cancer cells, most of the tumor-associated Ags are expressed at low but detectable levels in normal tissues. It is not clear whether the repertoire of T cellsExpand
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Piwil2 is expressed in various stages of breast cancers and has the potential to be used as a novel biomarker.
Piwil2, a member of AGO/PIWI family of proteins, has been reported to be expressed in precancerous stem cells (pCSCs), tumor cell lines and various types of human cancers. However, the significanceExpand
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Piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16.
Generally, cancers may undergo the developmental stages of benign proliferation, precancer and invasive cancer. Identification of biomarkers that are expressed throughout the developmental stagesExpand
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Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A‐induced hepatitis
Background and Aim:  Both nuclear factor kappa B (NF‐κB) activation and inducible nitric oxide synthase (iNOS) expression increase in the liver injury, and there are NF‐κB binding sites in the iNOSExpand
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