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Vascular endothelial growth factor (VEGF) promotes angiogenesis and plays important roles both in physiological and pathological conditions. VEGF receptors (VEGFRs) are high-affinity receptors for VEGF and are originally considered specific to endothelial cells. We previously reported that VEGFRs were also constitutively expressed in normal human(More)
In this study, the expression of neural precursor cell expressed developmentally downregulated 9 (NEDD9) in benign and malignant gastric tissues was investigated, and the significance of NEDD9 in gastric cancer prognosis was explored. Immunohistochemistry was used to detect NEDD9 expression in gastric cancer, nontumor gastric, and normal gastric tissues.(More)
Hyperactivity and its compensatory mechanisms may causally contribute to synaptic and cognitive deficits in Alzheimer's disease (AD). Blocking the overexcitation of the neural network, with levetiracetam (LEV), a sodium channel blocker applied in the treatment of epilepsy, prevented synaptic and cognitive deficits in human amyloid precursor protein (APP)(More)
In order to improve the speaker recognition accuracy, a new mel-frequency cepstral coefficient (MFCC) parameters extraction criterion based on F-Ratio and correlated distance criterion is proposed. Take the correlation of the characteristics into account, F-Ratio and correlated distance criterion (FRCDC) is proposed, which provides an idea about the(More)
In order to improve the speaker recognition accuracy, the pitch is applied to GMM-based speaker recognition (SR). The circular average magnitude difference function (CAMDF) method is used to extract the pitch. An endpoint detection method based on the pitch is proposed. The following four features are selected as the features of the SR: the mel-frequency(More)
An audio watermarking algorithm based on psychoacoustic model is proposed. The algorithm can resist the statistics attack. The frequency masking threshold of the audio is calculated through psychoacoustic model. The frequency masking threshold is used to estimate the strength of the watermark signal and determine the location of embedding. The watermark is(More)
The cerebellum plays an essential role in balance and motor coordination. Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex and are critical for the execution of its functions, including motor coordination. Toll-like receptor (TLR) 4 is involved in the innate immune response and is abundantly expressed in the central nervous system;(More)
A new Ru(II) complex [Ru(dmp)2(NMIP)](ClO4)2 (dmp = 2,9-dimethyl-1,10-phenanthroline, NMIP = 2’-(2″-nitro-3″,4″-methylenedioxyphenyl)imidazo[4′,5′-f][1,10]-phenanthroline) was synthesized and characterized by elemental analysis, ESI–MS and 1H NMR. The cytotoxic activity of the complex against MG-63, U2OS, HOS, and MC3T3-e1 cell lines was investigated by MTT(More)
Disrupted-in-Schizophrenia-1 (DISC1) is a genetic risk factor for a wide range of major mental disorders, including schizophrenia, major depression, and bipolar disorders. Recent reports suggest a potential role of DISC1 in the pathogenesis of Alzheimer's disease (AD), by referring to an interaction between DISC1 and amyloid precursor protein (APP), and to(More)
The knowledge regarding the importance of long non-coding RNAs (lncRNAs), a new class of genes, is very sparse in osteosarcoma. In the present study, we describe the expression profile of lncRNAs in osteosarcomas compared with paired adjacent non-cancerous tissue (n = 7) using microarray analysis. A total of 25,733 lncRNAs were identified in osteosarcoma;(More)
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