Jian-wei Zeng

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Signal transducer and activator of transcription 3 (STAT3) plays a critical role in cell survival and proliferation. Constitutive activation of STAT3 is strongly correlated with pathogenesis of various types of malignant tumors including colorectal cancer (CRC), and therefore is a major focus in the development of anti-cancer agents. Pien Tze Huang (PZH), a(More)
Eclipta prostrata, an aromatic plant, is known in Chinese herbal medicine for the treatment of various kidney diseases. In the present study, the volatile components were isolated from the aerial parts of this plant by hydrodistillation and analysed by GC-MS. A total of 55 compounds, which were the major part (91.7%) of the volatiles, were identified by(More)
The present study aimed to elucidate the molecular mechanisms underlying the induction of cytotoxic effects by sasanquasaponin (SQS) in HepG2 cells. Following SQS treatment, time- and dose-dependent increases in the apoptotic rate were observed. The induction of cell death by SQS mainly occurs via programmed cell death, as indicated by Annexin V-fluorescein(More)
Livistona chinensis seeds have been used for centuries to clinically treat various types of cancer. Our published data suggest that Livistona chinensis seeds are able to inhibit hepatocellular carcinoma (HCC) growth in vitro and in vivo via promotion of mitochondrial-dependent apoptosis. To further elucidate the molecular mechanisms of its antitumor(More)
We carried out a systematic research on antioxidant activities of ethanolic extracts of aerial parts (stems and leaves) of four selected Stevia rebaudiana lines. Total phenolics and flavonoids contents of different S. rebaudiana lines were in the range of 55.64–58.35 mg (gallic acid) g−1 dw and 48.29–60.33 mg (rutin) g−1 dw, respectively. The contents of(More)
OBJECTIVE To develop the characteristic chromatographic profile of Sarcandra glabra by HPLC for its quality control. METHOD The HPLC analysis was performed on an Agilent Zorbax Eclipse XDB-C18 column (4. 6 mm x 250 mm, 5 microm) with column temperature at 40 degree C. The mobile phase was consisted of water containing 0. 5% formic acid and acetonitrile to(More)
Postmenopausal osteoporosis (PMOP) is characterized by increased bone loss due to enhanced osteoclastogenesis and bone resorption. A Chinese herbal formula, jiangugranule (JG), exhibited great efficacy in the clinical treatment of PMOP. However, the molecular mechanisms underlying the therapeutic effects remain unclear. The present study aimed to examine(More)
OBJECTIVE To promote its comprehensive utilization, the involatile constituents of Mentha haplocalyx were studied systematically. METHOD The chemical components were isolated and purified by silca gel column chromatography and recrystallization. The chemical structures were elucidated on the basis of physico-chemical properties and spectral data. RESULT(More)
OBJECTIVE To explore the influence of steam killenzyme torrefaction on the quality of Camellia nitidissima. METHODS Based on the quality evaluation index, Camellia nitidissima was processed by steam killenzyme torrefaction and sun-dried. The contents of functional ingredients such as flavonoids, saponins, tea polyphenols, polysaccharides, amino acids, tea(More)
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers; therefore it is a major focus in the development of novel anti-cancer agents. Hedyotis diffusa Willd has been used as a major component in several Chinese medicine formulas for the clinical treatment of(More)