Jian-wei Shen

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The biotransformation of 3β-acetoxypregna-5,16-diene-20-one (1) by using a filamentous fungus Penicillium citrinum resulted in the production of four metabolites 2-5. The structures of these compounds were elucidated by different spectroscopic analysis (1D- and 2D-NMR) and HR-ESI-MS as 3β,7β-dihydroxy-pregn-5,16(17)-dien-20-one (2),(More)
For bone morphogenetic protein (BMP) gene therapy to be a viable approach for enhancing implant osseointegration clinically, requires the development of efficient nonviral delivery vectors that can coat the implant. This study evaluated a multilayer cationic liposome-DNA complex (LDc) coating as a delivery vehicle for recombinant human BMP-2 (rhBMP-2).(More)
PURPOSE To determine the thickness of the facial bone wall and the sagittal angulation between the long axis of the teeth and the long axis of the associated alveolar bone in the maxillary esthetic zone using cone beam computed tomography (CBCT). MATERIALS AND METHODS A retrospective radiographic study of CBCT images was conducted in 300 patients. The(More)
Storage in aqueous solution and ultraviolet (UV) photofunctionalization are two applicable methods to overcome the biological aging and increase the bioactivity of titanium. As information regarding the combined effects of storage medium and UV photofunctionalization has never been found in published literatures, this study focused on whether appropriate(More)
PURPOSE The objective of this study was to evaluate peri-implant bone formation and osseointegration at titanium implants coated with multiple layers of recombinant human bone morphogenetic protein-2 (rhBMP-2) cDNA placed into canine mandibles. MATERIALS AND METHODS The rhBMP-2 plasmid was assembled on sandblasted/dual-acid-etched pure titanium implant(More)
BACKGROUND AND AIM Endoscopic clearance of large or impacted stones in the main pancreatic duct (MPD) remains a clinical challenge. In this study, we attempted to technically modify the metallic stent to facilitate the clearance of large pancreatic stones in 4 patients, hoping to lower the operative risks and shorten hospital stay. PATIENTS AND METHODS(More)
OBJECTIVE To measure the thickness of facial bone wall of maxillary anterior teeth and premolars based on cone beam computed tomography (CBCT) images. METHODS CBCT images from 118 patients were collected from the Affiliated Stomatology Hospital of Zhejiang University. The thickness perpendicular to the long axis of facial bone wall was measured at two(More)
Two new benzochromone glycosides, rubrofusarin 6-O-alpha-L-rhamnosyl- (1 --> 6)-O-beta-D-glucopyranoside (1) and demethylflavasperone 10-O-beta-D-glucopyranoside (2), have been isolated from the stem of Berchemia racemosa Sieb. et Zucc. (Rhamnaceae). Their structures were elucidated on the basis of spectroscopic evidence.
PURPOSE The aim of this study was to compare strontium-containing implant (Sr-Ti) surfaces with modified pure Ti (Mod Ti) on the promotion of osteogenesis in vitro and in vivo. MATERIALS AND METHODS The Sr-Ti surfaces were fabricated by hydrothermal treatment. The Mod Ti surfaces were used as a control. These surfaces were characterized with scanning(More)