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Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
TLDR
This study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis, which is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors.
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Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys
TLDR
This is the first face-to-face nation-wide study in Chinese children aged 1–7 ys, revealing that the prevalence of AD in children is closer to that of wealthier nations.
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Clinical patterns and characteristics of ankylosing spondylitis in China
TLDR
The study aimed to determine whether unique clinical patterns of AS may exist in China, specifically to explore the different clinical manifestations caused by gender, HLA-B27 status, and age at disease onset, and found AAU was less common in Chinese patients.
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A Retrospective Study of Propranolol Therapy in 635 Infants with Infantile Hemangioma
Six hundred thirty‐five patients underwent oral propranolol treatment for infantile hemangioma. The efficacy rate was 91.2% and 162 of the patients recovered completely. No significant adverse…
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Novel phenotypes of NF1 patients from unrelated Chinese families with tibial pseudarthrosis and anemia
TLDR
The mutational spectrum of the NF1 gene associated with neurofibromatosis type1 is expanded, with a novel mutation and three previously reported mutations in these four probands causing disease phenotypes with rare phenotype.
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[Clinical features of onychomadesis following hand-foot-mouth disease in children].
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Prolonging Time to Flare in Pediatric Atopic Dermatitis: A Randomized, Investigator-Blinded, Controlled, Multicenter Clinical Study of a Ceramide-Containing Moisturizer
TLDR
A regimen incorporating a moisturizer plus body wash delayed AD flares by nearly 2 months compared to body wash alone, and yielded high patient satisfaction, and both products led to high customer satisfaction and were well tolerated.
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Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis
TLDR
Smoking is a risk factor for greater disease activity and worse functioning in patients with ankylosing spondylitis and current, former and ever smokers had significantly higher BASDAI (SMD’s = 0.34”) compared to non-smokers, and smokers had an increased risk of BASFI ≥ 4.
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Marked Reduction of Sacroiliac Joint Inflammation on Magnetic Resonance Imaging in a Patient with Ankylosing Spondylitis After Rituximab Treatment
TLDR
A patient with AS receiving rituximab who showed improvement in clinical outcomes as well as MRI findings is described, and there is no evidence that active inflammation on magnetic resonance imaging (MRI) in the spine or sacroiliac joints might be suppressed after treatment with ritUXimab.
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Phase 1 Study of TG-1701, a Selective Irreversible Inhibitor of Bruton's Tyrosine Kinase (BTK), in Patients with Relapsed/Refractory B-Cell Malignancies
TLDR
The primary objectives of the study are to characterize the safety profile and to determine the recommended Phase 2 dose of TG-1701 as a single agent and in combination with U2, and to assessment of pharmacokinetics (PK), preliminary antitumor activity, and pharmacodynamics (PD [BTK occupancy).
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