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Structural and Functional Study of d-Glucuronyl C5-epimerase*
  • Yi Qin, J. Ke, +12 authors K. Ding
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 7 January 2015
The crystal structures of Glce in apo-form and in complex with heparin hexasaccharide, both in a stable dimer conformation are determined, advancing understanding of the key modification in HS biosynthesis. Expand
Comparative Susceptibility of Japanese and European Eels to Infections with Pseudodactylogyrus spp. (Monogenea)
European eel was more susceptible not only to the first but also to the second and later generations of parasites than Japanese eel, which is the first experimental evidence that there are substantial differences in the susceptibility to P. anguillae. Expand
Heparin Impairs Angiogenesis through Inhibition of MicroRNA-10b*
Heparin attenuates miR-10b expression and induces HoxD10 expression in vivo to inhibit angiogenesis and impair the growth of MDA-MB-231 tumor xenografts, providing insight into the molecular mechanism by which heparin and thrombin regulateAngiogenesis. Expand
A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42.
It is shown that polysaccharide LJW0F2 could inhibit Aβ42 aggregation in a dose-dependent-manner and could attenuate the cytotoxicity induced by Aβ 42 aggregation in SH-SY5Y neuroblastoma cells. Expand
Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling
GFPBW1 potentiated the Concanavalin A-induced proliferative response of splenocytes and inhibited Sarcoma-180 growth allografted in ICR mice but not in immunodeficient BALB/c nu/nu mice, suggesting that the antitumor activity of GFP BW1 was partially associated with the activation of macrophages via the Dectin-1/Syk/NF-κB signaling pathway. Expand
Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa , through dectin-1 in macrophages.
The structure of a novel water-soluble homogeneous polysaccharide (GFPBW2) from the fruit bodies of mushroom Grifola frondosa is characterized and its immunomodulatory activity in vitro is investigated and suggested that GFP BW2 might be a potential ligand of Dectin-1. Expand
Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors.
Kinetic analysis of 3a inhibition showed that it is predominantly competitive with respect to D-luciferin and uncompetitive withrespect to ATP, and several pyrrolo[2,3-d]pyrimidine analogues were prepared to further investigate the structure-activity relationship (SAR) for luciferase inhibition. Expand
A review on the detoxification of organophosphorus compounds by microorganisms
Organophosphorus compounds (OPs) are widely used as pesticides and chemical warfare agents (CWAs). These synthetic compounds reside in the environment and cause serious pollution problems.Expand
Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects
Results indicated that only sulfated polysaccharides with molecular weights of more than 41,000 Da could inhibit HMEC-1 cell tube formation, and the inhibition effect was dependent on the presence of a sulfate group, since the tube formation was not blocked by aminopropylated, carboxymethylated, phosphorylated, or acetylated WGEW. Expand
Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
It appears that the structural alterations of HS affect the ability of TGF‐β1 to signal via its receptors and elicit a growth response, highlighting a crosstalk between heparanase, HS, and TGF-β1 function in tumorigenesis. Expand