Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial
UC‐MSC infusions are safe and could be beneficial in treating subjects with COVID‐19 ARDS and treatment was associated with significantly improved patient survival, SAE‐free survival, and time to recovery.
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.
Among patients undergoing renal transplant, the use of autologous MSCs compared with anti-IL-2 receptor antibody induction therapy resulted in lower incidence of acute rejection, decreased risk of opportunistic infection, and better estimated renal function at 1 year.
Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and…
Transplantation of UC-MSC and aBM-MNC was safe and associated with moderate improvement of metabolic measures in patients with established type 1 diabetes, and the treatment was well tolerated.
Electrosurgical enucleation versus bipolar transurethral resection for prostates larger than 70 ml: a prospective, randomized trial with 5-year followup.
Plasmakinetic enucleation of the prostate compared with open prostatectomy for prostates larger than 100 grams: a randomized noninferiority controlled trial with long-term results at 6 years.
Mesenchymal-stem-cell-based experimental and clinical trials: current status and open questions
This review aims at discussing the mechanisms of MSC-mediated immunomodulation and tissue repair and the related clinical trials, with special emphasis on factors that influence the efficiency of M SC-based therapy.
Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation
Exosomes derived from MSCs could protect beta cells against apoptosis induced by hypoxia, largely by carrying miR-21, alleviating ER stress and inhibiting p38 MAPK signalling, indicating that MSC exosomes might improve encapsulated islet survival and benefit diabetes patients.
CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy
The data indicate that CHOP may favor ER stress-induced apoptosis in HCC cells via inhibition of autophagy in vitro, which could partially resensitize ER stressed cells' apoptosis.
Mesenchymal Stem Cells Ameliorate Ischemia-Reperfusion-Induced Renal Dysfunction by Improving the Antioxidant/Oxidant Balance in the Ischemic Kidney
- W. Zhuo, L. Liao, T. Xu, Weizhen Wu, Shun-liang Yang, Jian-ming Tan
- Medicine, BiologyUrologia internationalis
- 28 September 2010
MSC infusion significantly improved kidney function as indicated by lower urea and creatinine levels in the MSC compared to the vehicle group and at histological examination, the kidneys of MSC-treated rats showed a fairly normal morphology.
Autologous bone marrow mononuclear cell infusion and hyperbaric oxygen therapy in type 2 diabetes mellitus: an open-label, randomized controlled clinical trial.