Jian-hui Xiao

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Medicinal higher fungi such as Cordyceps sinensis and Ganoderma lucidum have been used as an alternative medicine remedy to promote health and longevity for people in China and other regions of the world since ancient times. Nowadays there is an increasing public interest in the secondary metabolites of those higher fungi for discovering new drugs or lead(More)
Cordyceps, an entomopathogenic mushroom, is a famous traditional Chinese medicinal herb (TCM). This higher fungus contains various known and untapped bioactive metabolites, and is looked at as an important source of natural drugs while simultaneously provides good opportunities for discovering new drugs with immunomodulatory, antitumor, hypoglycemic and(More)
OBJECTIVE In an effort to investigate the chemical constitutes of submerged cultivation mycelium of Cordyceps jiangxiensis anamorph. METHODS The mycelia of C. jiangxiensis anamorph produced by submerged cultivation technique were separated and purified using various chromatographic techniques such as repeated liquid column chromatography, preparative thin(More)
Cordyceps taii, an edible medicinal mushroom native to south China, is recognized as an unparalleled resource of healthy foods and drug discovery. In the present study, the antioxidant pharmacological properties of C. taii were systematically investigated. In vitro assays revealed the scavenging activities of the aqueous extract and polysaccharides of C.(More)
PURPOSE An increase of matrix metalloproteinase-2 (MMP-2) has been found to improve outflow through the uveoscleral pathway. This experiment was designed to test whether reduction of inhibitor of nuclear factor kappa B alpha (IkappaBalpha) levels could enhance MMP-2 expression in human ciliary muscle (HCM) cells in vitro. METHODS The small interfering RNA(More)
A new compound, named jiangxienone, has been isolated from a culture of the traditional Chinese medicinal mushroom Cordyceps jiangxiensis, and its chemical structure was established on the basis of spectroscopic and chemical techniques. Jiangxienone showed potent cytotoxic effects against human gastric adenocarcinoma SGC-7901 cell and human lung carcinoma(More)
BACKGROUND Cordyceps taii, an entomogenous fungus native to south China, is a folk medicine with varieties of pharmacological activities including anticancer effect. To validate the ethnopharmacological claim against cancer, the antitumor and antimetastatic activities of chloroform extract of C. taii (CFCT) were investigated in vivo. METHODS The in vitro(More)
The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. Doses of 10 and 20 mg/kg/day helvolic acid did not(More)
Three new cytochalasins (1-3) together with two known cytochalasin analogues (4 and 5) were isolated from the chloroform fraction of ethanolic extract of a medicinal macrofungus Cordyceps taii. The structures of the new compounds were elucidated on the basis of spectroscopic analysis, including HRESIMS, 1D and 2D NMR experiments. The cytotoxicities of(More)
Cordyceps is a precious medical fungi resource, with diverse metabolites and bioactive. There is huge prospect for its applicaiton in functional food and biomedicine fields. Cordyceps has abundant species resources, particularly Cordyceps sinensis is one of three most precious traditional Chinese restoratives in China. The essay summarizes the latest(More)