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Wavelength interval selection in multicomponent spectral analysis by moving window partial least-squares regression with applications to mid-infrared and near-infrared spectroscopic data.
It is shown that MWPLSR provides a viable approach to eliminate the extra variability generated by non-composition-related factors such as the perturbations in experimental conditions and physical properties of samples.
Modified particle swarm optimization algorithm for variable selection in MLR and PLS modeling: QSAR studies of antagonism of angiotensin II antagonists.
Spectral regions selection to improve prediction ability of PLS models by changeable size moving window partial least squares and searching combination moving window partial least squares
Principles and methodologies in self-modeling curve resolution
Surface-enhanced Raman spectroscopy-based, homogeneous, multiplexed immunoassay with antibody-fragments-decorated gold nanoparticles.
The developed SERS immunoassay platform may create a simple but valuable tool for facilitating accurate validation and early detection of disease biomarkers as well as for point-of-care tests in clinical diagnostics.
Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection.
- Haixin Chang, Longhua Tang, Ying Wang, Jian-hui Jiang, Jinghong Li
- ChemistryAnalytical chemistry
- 24 February 2010
A highly sensitive and specific fluorescence resonance energy transfer (FRET) aptasensor for thrombin detection is developed based on the dye labeled aptamer assembled graphene, which exhibits extraordinarily high sensitivity and excellent specificity in both buffer and blood serum.
Aptamers from cell-based selection for bioanalytical applications.
This research presents a novel probabilistic approach to genome-based approaches to personalized medicine that exploits the “cell reprograming” mechanism to characterize the immune system through “disease-fighting” cells.
Highly sensitive and selective strategy for microRNA detection based on WS2 nanosheet mediated fluorescence quenching and duplex-specific nuclease signal amplification.
WS2 nanosheet can exhibit differential affinity toward short oligonucleotide fragment versus ssDNA probe and act as an efficient quencher for adsorbed fluorescent probes and indicates that this simple and cost-effective strategy holds great potential application in biomedical research and clinical diagnostics.
Electrochemical sensor for mercury(II) based on conformational switch mediated by interstrand cooperative coordination.
A novel electrochemical sensor was developed for sensitive and selective detection of mercury(II), based on thymine-Hg2+-thymine (T- Hg2-T) coordination chemistry, which afforded exquisite selectivity for H g2+ against a reservoir of other environmentally related metal ions, compared to existing anodic stripping voltammetry (ASV) techniques.
Rolling circle amplification combined with gold nanoparticle aggregates for highly sensitive identification of single-nucleotide polymorphisms.
A highly sensitive and specific colorimetry-based rolling circle amplification (RCA) assay method for single-nucleotide polymorphism genotyping has been developed, resulting in positive detection of mutant targets even when the ratio of the wild-type to the mutant is 10,000:1.