Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling.
- Wenhua Zhang, C. Qin, Jian Zhao, Xuemin Wang
- Biology, Environmental ScienceProceedings of the National Academy of Sciences…
- 22 June 2004
The identification of ABI1 as a direct target of the lipid messenger PA provides a functional link between the two families of important signaling enzymes, PLD and PP2C.
A Bifurcating Pathway Directs Abscisic Acid Effects on Stomatal Closure and Opening in Arabidopsis
- G. Mishra, Wenhua Zhang, F. Deng, Jian Zhao, Xuemin Wang
- Environmental ScienceScience
- 14 April 2006
Terrestrial plants lose water primarily through stomata, pores on the leaves. The hormone abscisic acid (ABA) decreases water loss by regulating opening and closing of stomata. Here, we show that…
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.
- C. Mayer, Jian Zhao, Xuejun Yuan, I. Grummt
- Biology, ChemistryGenes & Development
- 15 February 2004
It is shown that the mammalian target of rapamycin regulates Pol I transcription by modulating the activity of TIF-IA, a regulatory factor that senses nutrient and growth-factor availability and elucidate the molecular mechanism underlying mTOR-dependent regulation of RNA synthesis.
Nuclear actin and myosin I are required for RNA polymerase I transcription
- V. Philimonenko, Jian Zhao, I. Grummt
- BiologyNature Cell Biology
- 1 December 2004
Investigation of the role of actin and nuclear myosin I in the transcription of ribosomal RNA genes (rDNA) suggests a role for NMI in the growth-dependent regulation of rRNA synthesis.
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.
- Jian Zhao, Xuejun Yuan, M. Frödin, I. Grummt
- BiologyMolecules and Cells
- 1 February 2003
Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription.
- Jing Ye, Jian Zhao, U. Hoffmann‐Rohrer, I. Grummt
- BiologyGenes & Development
- 1 February 2008
The results show that actin polymerization and the motor function of NM1 are required for association with the Pol I transcription machinery and transcription activation, and reveal an actomyosin-based mechanism in transcription.
Plant phospholipases D and C and their diverse functions in stress responses.
- Yueyun Hong, Jian Zhao, Xuemin Wang
- Biology, ChemistryProgress in lipid research
- 1 April 2016
The Synaptonemal Complex Protein SCP3 Can Form Multistranded, Cross-striated Fibers In Vivo
- Li Yuan, J. Pelttari, C. Höög
- BiologyJournal of Cell Biology
- 27 July 1998
It is proposed that SCP3 fibers constitute the core of the lateral elements of the synaptonemal complex and function as a molecular framework to which other proteins attach, regulating DNA binding to the chromatid axis, sister Chromatid cohesion, synapsis, and recombination.
Arabidopsis Phospholipase Dα1 Interacts with the Heterotrimeric G-protein α-Subunit through a Motif Analogous to the DRY Motif in G-protein-coupled Receptors*
- Jian Zhao, Xuemin Wang
- Biology, ChemistryJournal of Biological Chemistry
- 16 January 2004
These results have demonstrated the direct binding between Gα and PLDα1, identified the DRY motif on PLDalpha1 as the site for the interaction, and indicated that the interaction modulates reciprocally the activities of PLD α1 and Gα.
Arabidopsis phospholipase Dβ1 modulates defense responses to bacterial and fungal pathogens.
- Jian Zhao, S. Devaiah, Cunxi Wang, Maoyin Li, R. Welti, Xuemin Wang
- Environmental ScienceNew Phytologist
- 1 July 2013
Infection of phospholipase D β1-deficient plants by Pseudomonas syringae tomato pv DC3000 resulted in less bacterial growth than in wild-type plants, and the effect was more profound in virulent Pst DC3000 than avirulent PSt DC3000 (carrying the avirulence gene avrRpt2) infection.
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