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DNA-encoded chemical libraries (DELs) are a cost-effective technology for the discovery of novel chemical probes and drug candidates. A major limiting factor in assembling productive DELs is the… Continue Reading
Enantiodivergent catalyst systems were developed using metals with different ionic radii and a multifunctional brucine diol (BD) ligand. The catalytic use of purported 1:1 Cu-BD complexes in the… Continue Reading
Li, Jian-Yuan Ph.D., Purdue University, December 2014. The Modification of Brucine Derivatives as Chiral Ligands and Its Application in the Asymmetric Synthesis. Major Professor: Robert Minto. The… Continue Reading
Stereodivergent catalytic asymmetric conjugate reactions of glycine (ket)imines with nitroalkenes have been achieved using various chiral catalyst systems derived from a multidentate amino alcohol… Continue Reading
Enantio- and diastereodivergent approaches to pyrrolidines are described by using catalyst- and substrate-controlled reaction pathways. A concerted endo-selective [3 + 2]-cycloaddition pathway is… Continue Reading
The brucine N-oxide promoted Morita-Baylis-Hillman (MBH) reaction of vinyl ketones with aldehydes has been achieved. The corresponding asymmetric version of MBH reaction was also investigated, and… Continue Reading
A concerted pathway for the endo-selective [3 + 2]-cycloaddition of methyl imino ester with nitroalkenes is developed.